Stage IVA Prostate Cancer Clinical Trials

1 recruiting

Stage IVA Prostate Cancer Trials at a Glance

17 actively recruiting trials for stage iva prostate cancer are listed on ClinicalTrialsFinder across 6 cities in 7 countries. The largest study group is Phase 2 with 7 trials, with the heaviest enrollment activity in Los Angeles, Houston, and Effingham. Lead sponsors running stage iva prostate cancer studies include M.D. Anderson Cancer Center, Jonsson Comprehensive Cancer Center, and City of Hope Medical Center.

Browse stage iva prostate cancer trials by phase

Treatments under study

About Stage IVA Prostate Cancer Clinical Trials

Looking for clinical trials for Stage IVA Prostate Cancer? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Stage IVA Prostate Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Stage IVA Prostate Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 117 of 17 trials

Recruiting
Not Applicable

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

Metastatic Malignant Solid NeoplasmMetastatic MelanomaMetastatic Renal Cell Carcinoma+15 more
M.D. Anderson Cancer Center40 enrolled1 locationNCT04693377
Recruiting
Phase 1Phase 2

Abemaciclib Before 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer

Castration-Resistant Prostate CarcinomaStage IV Prostate Cancer AJCC v8Stage IVB Prostate Cancer AJCC v8+2 more
Vadim S Koshkin30 enrolled1 locationNCT05113537
Recruiting
Phase 3

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Stage III Prostate Cancer AJCC v8Prostate AdenocarcinomaStage IVA Prostate Cancer AJCC v8
NRG Oncology1,209 enrolled398 locationsNCT05946213
Recruiting
Not Applicable

Accuracy of 18F-rhPSMA-7.3 PET/ MRI for Prediction of Lymph Node Metastasis in Localized High-Risk Prostate Cancer

Stage III Prostate Cancer AJCC v8Localized Prostate CarcinomaStage I Prostate Cancer AJCC v8+3 more
Mayo Clinic50 enrolled1 locationNCT06389786
Recruiting
Not Applicable

Nutrition and Exercise Interventions in Reducing Androgen Deprivation Therapy-Induced Obese Frailty in Prostate Cancer Survivors

ObesityProstate AdenocarcinomaCancer Survivor+17 more
Roswell Park Cancer Institute50 enrolled1 locationNCT03880422
Recruiting
Phase 1

Image-Guided Biopsies to Identify Mechanisms of Resistance in Patients With Metastatic Castration Resistant Prostate Cancer Treated With 177Lu-PSMA Radioligand Therapy

Castration-Resistant Prostate CarcinomaMetastatic Prostate CarcinomaStage IVB Prostate Cancer AJCC v8+2 more
Jonsson Comprehensive Cancer Center30 enrolled1 locationNCT05398302
Recruiting
Phase 3

REVELUTION-2: Relugolix+Abiraterone Acetate (AA) Versus Leuprolide+AA Cardiac Trial

Recurrent Prostate CarcinomaStage III Prostate Cancer AJCC v8Stage IVA Prostate Cancer AJCC v8
Emory University72 enrolled4 locationsNCT06650579
Recruiting
Phase 2

Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer

Prostate CarcinomaStage III Prostate Cancer AJCC v8Stage IVA Prostate Cancer AJCC v8+4 more
M.D. Anderson Cancer Center200 enrolled1 locationNCT04947254
Recruiting
Phase 2

Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate Cancer

Stage IV Prostate Cancer AJCC v8Stage IVB Prostate Cancer AJCC v8Metastatic Prostate Adenocarcinoma+2 more
City of Hope Medical Center70 enrolled1 locationNCT04734730
Recruiting
Phase 3

Vitamin D for Prostate Endocrine Therapy

Stage III Prostate Cancer AJCC v8Stage I Prostate Cancer AJCC v8Stage II Prostate Cancer AJCC v8+1 more
University of Rochester240 enrolled51 locationsNCT05838716
Recruiting
Phase 3

Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer, INNOVATE Trial

Stage III Prostate Cancer AJCC v8Prostate AdenocarcinomaStage I Prostate Cancer AJCC v8+2 more
NRG Oncology586 enrolled347 locationsNCT04134260
Recruiting
Phase 3

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

Stage IV Prostate Cancer AJCC v8Stage IVB Prostate Cancer AJCC v8Stage IVA Prostate Cancer AJCC v8+2 more
SWOG Cancer Research Network1,273 enrolled338 locationsNCT03678025
Recruiting
Phase 2

Time-Restricted Eating Versus Nutritional Counseling for the Reduction of Radiation or Chemoradiation Tx Side Effects in Patients With Prostate, Cervical, or Rectal Cancers

Malignant Solid NeoplasmLocally Advanced Cervical CarcinomaRecurrent Prostate Carcinoma+15 more
City of Hope Medical Center60 enrolled1 locationNCT05722288
Recruiting
Not Applicable

High Dose-Rate Brachytherapy and Stereotactic Body Radiotherapy for the Treatment of Prostate Adenocarcinoma

Stage III Prostate Cancer AJCC v8Prostate AdenocarcinomaStage IVA Prostate Cancer AJCC v8+5 more
Jonsson Comprehensive Cancer Center52 enrolled1 locationNCT04945642
Recruiting
Phase 2

Extremely Hypofractionated Intensity Modulated Stereotactic Body Radiotherapy for the Treatment of Prostate Cancer With Rising PSA After Radical Prostatectomy

Stage IV Prostate Cancer AJCC v8Stage IVB Prostate Cancer AJCC v8Prostate Adenocarcinoma+3 more
Jonsson Comprehensive Cancer Center102 enrolled1 locationNCT04915508
Recruiting
Phase 2

Cabozantinib and Atezolizumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer, The AtezoCab Trial

Castration-Resistant Prostate CarcinomaStage IV Prostate Cancer AJCC v8Stage IVB Prostate Cancer AJCC v8+2 more
University of Utah33 enrolled1 locationNCT05168618
Recruiting
Phase 2

Modifying Metabolic Syndrome and Cardiovascular Risk for Prostate Cancer Patients on ADT Using a Risk Factor Modification Program and Continuous Fitbit Monitoring

Stage IV Prostate Cancer AJCC v8Stage IVB Prostate Cancer AJCC v8Metastatic Prostate Adenocarcinoma+2 more
M.D. Anderson Cancer Center200 enrolled1 locationNCT05054296