Stage IV Prostate Cancer Clinical Trials

1 recruiting

Stage IV Prostate Cancer Trials at a Glance

22 actively recruiting trials for stage iv prostate cancer are listed on ClinicalTrialsFinder across 6 cities in 5 countries. The largest study group is Phase 2 with 11 trials, with the heaviest enrollment activity in Duarte, Houston, and Scottsdale. Lead sponsors running stage iv prostate cancer studies include Mayo Clinic, City of Hope Medical Center, and Jonsson Comprehensive Cancer Center.

Browse stage iv prostate cancer trials by phase

Treatments under study

About Stage IV Prostate Cancer Clinical Trials

Looking for clinical trials for Stage IV Prostate Cancer? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Stage IV Prostate Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Stage IV Prostate Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 22 trials

Recruiting
Phase 2

Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells

Stage IV Prostate Cancer AJCC v8Metastatic Prostate Small Cell Neuroendocrine CarcinomaMetastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation+1 more
National Cancer Institute (NCI)30 enrolled13 locationsNCT05691465
Recruiting
Not Applicable

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

Metastatic Malignant Solid NeoplasmMetastatic MelanomaMetastatic Renal Cell Carcinoma+15 more
M.D. Anderson Cancer Center40 enrolled1 locationNCT04693377
Recruiting
Phase 1Phase 2

Abemaciclib Before 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer

Castration-Resistant Prostate CarcinomaStage IV Prostate Cancer AJCC v8Stage IVB Prostate Cancer AJCC v8+2 more
Vadim S Koshkin30 enrolled1 locationNCT05113537
Recruiting
Not Applicable

Peer Navigation for the Support of Metastatic Prostate Cancer Patients Undergoing Genetic Evaluation

Metastatic Prostate CarcinomaStage III Prostate Cancer AJCC v8Stage IV Prostate Cancer AJCC v8
Thomas Jefferson University120 enrolled1 locationNCT05487846
Recruiting
Phase 2

Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations

Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast Carcinoma+28 more
National Cancer Institute (NCI)36 enrolled4 locationsNCT04550494
Recruiting

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

Head and Neck CarcinomaMalignant Solid NeoplasmSarcoma+59 more
Alliance for Clinical Trials in Oncology2,000 enrolled745 locationsNCT05334069
Recruiting
Not Applicable

Nutrition and Exercise Interventions in Reducing Androgen Deprivation Therapy-Induced Obese Frailty in Prostate Cancer Survivors

ObesityProstate AdenocarcinomaCancer Survivor+17 more
Roswell Park Cancer Institute50 enrolled1 locationNCT03880422
Recruiting
Phase 1

Image-Guided Biopsies to Identify Mechanisms of Resistance in Patients With Metastatic Castration Resistant Prostate Cancer Treated With 177Lu-PSMA Radioligand Therapy

Castration-Resistant Prostate CarcinomaMetastatic Prostate CarcinomaStage IVB Prostate Cancer AJCC v8+2 more
Jonsson Comprehensive Cancer Center30 enrolled1 locationNCT05398302
Recruiting
Phase 2

Evaluating In Home Cancer Therapy Versus In Clinic Cancer Therapy in Black Men With Locally Advanced, Biochemically Recurrent and Metastatic Prostate Cancer

Locally Advanced Prostate CarcinomaMetastatic Prostate CarcinomaStage III Prostate Cancer AJCC v8+2 more
Mayo Clinic38 enrolled1 locationNCT07073794
Recruiting
Phase 2

Androgen Deprivation Therapy (Relugolix) for the Improvement of Diagnostic Imaging (PSMA PET/CT Scan) in Patients With High Risk or Very High Risk Prostate Cancer, The EnrichPSMA Trial

Stage III Prostate Cancer AJCC v8Stage IV Prostate Cancer AJCC v8Prostate Adenocarcinoma+1 more
Mayo Clinic30 enrolled1 locationNCT07025369
Recruiting
Phase 2

Abiraterone and Prednisone or Darolutamide for the Treatment of Advanced Prostate Cancer

Stage III Prostate Cancer AJCC v8Stage IV Prostate Cancer AJCC v8Advanced Prostate Adenocarcinoma
University of California, Davis75 enrolled1 locationNCT06173362
Recruiting
Early Phase 1

Immunological Effects of Vitamin D Replacement Among Black/African American Prostate Cancer Patients

Metastatic Prostate CarcinomaStage IV Prostate Cancer AJCC v8Localized Prostate Carcinoma+1 more
Mayo Clinic220 enrolled2 locationsNCT05045066
Recruiting
Phase 2

Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate Cancer

Stage IV Prostate Cancer AJCC v8Stage IVB Prostate Cancer AJCC v8Metastatic Prostate Adenocarcinoma+2 more
City of Hope Medical Center70 enrolled1 locationNCT04734730
Recruiting
Phase 3

SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma

Stage III Prostate Cancer AJCC v8Stage IV Prostate Cancer AJCC v8Biochemically Recurrent Prostate Carcinoma+4 more
Mayo Clinic118 enrolled6 locationsNCT06205316
Recruiting

Collecting and Studying Blood and Tissue Samples From Patients With Locally Recurrent or Metastatic Prostate or Bladder/Urothelial Cancer

Malignant Solid NeoplasmRecurrent Prostate CarcinomaStage IV Bladder Cancer AJCC v7+8 more
University of Washington1,500 enrolled1 locationNCT01050504
Recruiting
Phase 2

Bright White Light Therapy in Reducing Cancer-Related Fatigue and Depression in Advanced Prostate Cancer Patients Undergoing Treatment With ADT Combination Therapy

Prostate CarcinomaMetastatic Prostate CarcinomaStage III Prostate Cancer AJCC v8+2 more
City of Hope Medical Center210 enrolled1 locationNCT05869682
Recruiting

Study to Detect Changes in Urinary and Gut Microbiome During Androgen Deprivation Therapy and Radiation Therapy in Patients With Prostate Cancer

Stage I Prostate Cancer AJCC v7Stage II Prostate Cancer AJCC v7Stage III Prostate Cancer AJCC v7+3 more
City of Hope Medical Center30 enrolled1 locationNCT04775355
Recruiting
Phase 3

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

Stage IV Prostate Cancer AJCC v8Stage IVB Prostate Cancer AJCC v8Stage IVA Prostate Cancer AJCC v8+2 more
SWOG Cancer Research Network1,273 enrolled338 locationsNCT03678025
Recruiting
Phase 2

Extremely Hypofractionated Intensity Modulated Stereotactic Body Radiotherapy for the Treatment of Prostate Cancer With Rising PSA After Radical Prostatectomy

Stage IV Prostate Cancer AJCC v8Stage IVB Prostate Cancer AJCC v8Prostate Adenocarcinoma+3 more
Jonsson Comprehensive Cancer Center102 enrolled1 locationNCT04915508
Recruiting

Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network

Metastatic Prostate CarcinomaStage IV Prostate Cancer AJCC v8Stage IIIB Prostate Cancer AJCC v8+1 more
Thomas Jefferson University30 enrolled1 locationNCT05627219