Early Phase 1 STI Clinical Trials
66 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 66 trials
Recruiting
Early Phase 1
Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia
City of Hope Medical Center15 enrolled1 locationNCT06735690
Recruiting
Early Phase 1
A Clinical Study Evaluating the Safety and Efficacy of GT801 Injection in Adult Patients With Relapsed/Refractory CD19-positive B-cell Hematologic Malignancies and Autoimmune Hemolytic Anemia
Chronic Lymphocytic Leukemia (CLL)B-cell Acute Lymphoblastic Leukemia (B-ALL)B-cell Non-Hodgkin's Lymphoma (B-NHL)
Grit Biotechnology28 enrolled2 locationsNCT07205315
Recruiting
Early Phase 1
Multi-modality Imaging and Collection of Biospecimen Samples in Understanding Bone Marrow Changes in Patients With Acute Myeloid Leukemia Undergoing TBI and Chemotherapy
Acute Lymphoblastic LeukemiaAcute Myeloid Leukemia
City of Hope Medical Center74 enrolled1 locationNCT03422731
Recruiting
Early Phase 1
Momelotinib in Combination With Hypomethylating Agent for Chronic Phase Myelodysplastic Syndromes/Myeloproliferative Overlap Neoplasms and Chronic Neutrophilic Leukemia
Myelodysplastic SyndromesChronic Myelomonocytic LeukemiaMyeloproliferative Overlap Neoplasms+1 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins18 enrolled1 locationNCT07071155
Recruiting
Early Phase 1
Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis
Cystic Fibrosis
University of Cincinnati61 enrolled1 locationNCT06163482
Recruiting
Early Phase 1
Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA CAR-NK Cell Injection for the Treatment of Refractory Pediatric Rheumatic Diseases
Systemic Lupus Erythematosus (SLE)Rheumatic DiseasesPediatric Rheumatological Condition (i.e., Arthritis, SLE, Kawasaki's Disaese)+1 more
The Children's Hospital of Zhejiang University School of Medicine36 enrolled1 locationNCT07490041
Recruiting
Early Phase 1
Hydroxychloroquine in Children's Interstitial Lung Diseases With Genetic Causes
Interstitial Lung DiseaseSurfactant Dysfunction
Children's Hospital of Fudan University60 enrolled1 locationNCT04532346
Recruiting
Early Phase 1
A Clinical Study Exploring the Safety, Efficacy and Cell Metabolic Kinetics of Universal Car-t Cell Injection in CD19 and / or CD20 Positive Relapsed / Refractory B-cell Acute Lymphoblastic Leukemia in Adolescents, Children and Adults
ALL (Acute B-Lymphoblastic Leukemia)
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology18 enrolled1 locationNCT07470073
Recruiting
Early Phase 1
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
GlioblastomaGlioblastoma MultiformeHigh Grade Glioma+6 more
Nationwide Children's Hospital15 enrolled18 locationsNCT06333899
Recruiting
Early Phase 1
Topical or Oral Minoxidil for the Treatment of Endocrine Therapy-Induced Alopecia in Patients With Stage I-IV Breast Cancer
Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8+20 more
Ohio State University Comprehensive Cancer Center50 enrolled1 locationNCT05417308
Recruiting
Early Phase 1
PhI Pilot Study Pafolacianine Inject for Intraoperative Imaging on Outcomes of GI Cancer Peritoneal Carcinomatosis
Peritoneal CarcinomatosisGastrointestinal Cancer
University of California, Irvine10 enrolled1 locationNCT06511037
Recruiting
Early Phase 1
Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
Alzheimer DiseaseMild Cognitive ImpairmentLogopenic Progressive Aphasia+1 more
Massachusetts General Hospital30 enrolled1 locationNCT06538311
Recruiting
Early Phase 1
68Ga-FAPI-46 PET/CT for Assessing Small Bowel Fibrostenosis in Crohn's Disease
Crohn's DiseaseIntestinal FibrosisInflamatory Bowel Disease+1 more
Mayo Clinic45 enrolled1 locationNCT07273188
Recruiting
Early Phase 1
The Effect of Therapy Combination in PCOS With Dlbs 3233
Polycystic Ovary Syndrome
Inlacinpenelitian90 enrolled1 locationNCT07403201
Recruiting
Early Phase 1
In-Human CXCR4 Imaging of Hematologic and Solid Tumors Using [68Ga]-Pentixafor-PET
Non-Hodgkin LymphomaMultiple MyelomaErdheim-Chester Disease+1 more
Memorial Sloan Kettering Cancer Center30 enrolled1 locationNCT05093335
Recruiting
Early Phase 1
Personalized Theratyping Trial
Cystic Fibrosis
George Solomon20 enrolled1 locationNCT03587961
Recruiting
Early Phase 1
[177Lu]Lu-AKIR001 First-in-human Study
Thyroid Gland Anaplastic CarcinomaPoorly Differentiated Thyroid CarcinomaCancer Head and Neck+3 more
Karolinska University Hospital15 enrolled1 locationNCT06639191
Recruiting
Early Phase 1
Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers
Head and Neck CancerSquamous Cell Carcinoma of Head and NeckSalivary Gland Cancer+1 more
Brigham and Women's Hospital30 enrolled2 locationsNCT05553782
Recruiting
Early Phase 1
Regional Monitoring of CF Lung Disease
Cystic Fibrosis
Children's Hospital Medical Center, Cincinnati60 enrolled1 locationNCT06339593
Recruiting
Early Phase 1
CART123 T Cells in Relapsed or Refractory CD123+ Hematologic Malignancies: A Dose Escalation Phase I Trial
Myelodysplastic Syndromes (MDS)Precursor Cell Lymphoblastic Leukemia-LymphomaBlastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)+1 more
Institute of Hematology and Blood Transfusion, Czech Republic18 enrolled1 locationNCT06765876