Early Phase 1 Stoma Clinical Trials
29 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 29 trials
Recruiting
Early Phase 1
Dosimetry, Safety, and Efficacy Study of [177Lu]Lu-XT771 in Patients With Recurrent Glioblastoma
Recurrent Glioblastoma, IDH-WildtypeGlioblastoma (GBM)Recurrent Glioblastoma+1 more
Beijing Tiantan Hospital5 enrolled2 locationsNCT07648823
Recruiting
Early Phase 1
Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation
NeuroblastomaPineoblastomaAtypical Teratoid/Rhabdoid Tumor+11 more
C17 Council15 enrolled12 locationsNCT06942039
Recruiting
Early Phase 1
Neoadjuvant Chemoradiotherapy With or Without Concurrent Azeliragon in Patients With Newly Diagnosed Glioblastoma
Glioblastoma
Washington University School of Medicine12 enrolled1 locationNCT06831526
Recruiting
Early Phase 1
BGB-58067 in Newly Diagnosed Glioblastoma Patients With MTAP-Deleted Tumors
Glioblastoma (GBM)
Nader Sanai78 enrolled1 locationNCT07485049
Recruiting
Early Phase 1
Senicapoc and Perampanel for Newly Diagnosed Glioblastoma
Glioblastoma
Aarhus University Hospital36 enrolled1 locationNCT07284069
Recruiting
Early Phase 1
A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies.
PineoblastomaMedulloblastoma RecurrentHigh-Grade Gliomas+4 more
Children's National Research Institute18 enrolled1 locationNCT07017816
Recruiting
Early Phase 1
Evaluating Safety, Tolerability, and Preliminary Efficacy of YSCH-01 Monotherapy and in Combination With Atezolizumab for Recurrent Glioblastoma
Recurrent Glioblastoma
Huashan Hospital10 enrolled1 locationNCT07538128
Recruiting
Early Phase 1
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
GlioblastomaGlioblastoma MultiformeHigh Grade Glioma+6 more
Nationwide Children's Hospital15 enrolled18 locationsNCT06333899
Recruiting
Early Phase 1
A Phase 0/1 Clinical Trial With an Expansion Phase of GSK5764227, a B7-H3-Targeted Antibody-Drug Conjugate (ADC), in Patients With Recurrent Grade 4 Glioma and Patients With Brain Metastases
Brain MetastasasesGlioblastoma (GBM)
Nader Sanai15 enrolled1 locationNCT07268053
Recruiting
Early Phase 1
Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma
Recurrent GlioblastomaProgressive Glioblastoma
Mayo Clinic8 enrolled1 locationNCT07076472
Recruiting
Early Phase 1
PET-imaging of Two Vartumabs in Patients With Solid Tumors
Breast CancerBladder CarcinomaEsophageal Carcinoma+11 more
Var2 Pharmaceuticals32 enrolled1 locationNCT06645808
Recruiting
Early Phase 1
Atezolizumab and Pre-Surgical Brain Radiation Therapy for Glioblastoma Multiforme
Glioblastoma Multiforme
Stony Brook University12 enrolled1 locationNCT05423210
Recruiting
Early Phase 1
Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma
GlioblastomaRecurrent GlioblastomaGlioblastoma Multiforme of Brain
Abramson Cancer Center at Penn Medicine15 enrolled2 locationsNCT06613841
Recruiting
Early Phase 1
A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions
GlioblastomaHigh Grade Glioma
St. Joseph's Hospital and Medical Center, Phoenix82 enrolled2 locationsNCT06072586
Recruiting
Early Phase 1
A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma
Brain TumorGlioblastomaRecurrent Glioblastoma
Ugonma Chukwueke27 enrolled3 locationsNCT06552260
Recruiting
Early Phase 1
Safety & Efficacy of IR-101 in Relapsed/Refractory Neuroblastoma
Neuroblastoma
Sichuan University10 enrolled2 locationsNCT07067346
Recruiting
Early Phase 1
Implantable Microdevice In Primary Brain Tumors
GlioblastomaAstrocytomaGrade II Glioma+5 more
Oliver Jonas12 enrolled1 locationNCT04135807
Recruiting
Early Phase 1
Clinical Evaluation of [68Ga]Ga-XT771 PET for Diagnosis in Patients With Glioblastoma and Clear Cell Renal Cell Carcinoma
Clear Cell Renal Cell Carcinoma and Glioblastoma
Chinese PLA General Hospital15 enrolled1 locationNCT07067905
Recruiting
Early Phase 1
Targeting NUDT21 siRNA Drugs for Patients With Refractory Retinoblastoma
RefractoryRetinoblastoma
Eye & ENT Hospital of Fudan University2 enrolled1 locationNCT06424301
Recruiting
Early Phase 1
Clinical Trial of BMS-986504 in Recurrent GBM Patients
Glioblastoma WHO Grade IV
Nader Sanai9 enrolled1 locationNCT06883747