Transgender Clinical Trials

28 recruitingLast updated: June 21, 2026

There are 28 actively recruiting transgender clinical trials across 11 countries. Studies span Not Applicable, Phase 4, Phase 2. Top locations include Ghent, East-Flanders, Belgium, Aurora, Colorado, United States, Odense, Denmark. Updated daily from ClinicalTrials.gov.


Transgender Trials at a Glance

28 actively recruiting trials for transgender are listed on ClinicalTrialsFinder across 6 cities in 11 countries. The largest study group is Not Applicable with 5 trials, with the heaviest enrollment activity in Ghent, Aurora, and Odense. Lead sponsors running transgender studies include University Hospital, Ghent, University of Colorado, Denver, and University Ghent.

Browse transgender trials by phase

Treatments under study

About Transgender Clinical Trials

Looking for clinical trials for Transgender? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Transgender trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Transgender clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 28 trials

Recruiting

Sex-differential Host-microbiome CVD Risk - A Longitudinal Cohort Approach

Immune SystemGut MicrobiomeTransgender+1 more
Charite University, Berlin, Germany200 enrolled1 locationNCT05334888
Recruiting

Swiss ProspectivE Cohort of TRAnsgender and Gender Diverse Individuals - The SPECTRA Study

Gender IncongruenceTransgender Individuals
University Hospital, Basel, Switzerland600 enrolled2 locationsNCT06774053
Recruiting

The Effect of Gender-affirmative Measures on Breast Perception in Trans Men

TransgenderGender Dysphoria in Adolescents and Adults
Medical University Innsbruck100 enrolled1 locationNCT07252687
Recruiting

Research Participation With Transgender and Gender-Diverse Youth

Transgender Persons
Virginia Commonwealth University250 enrolled1 locationNCT05927350
Recruiting
Phase 4

Investigating Gender and Sex Differences in Immune Responses Through Vaccination of Transgender and Cisgender Persons

VaccinationTransgender PersonsMeningococcal Meningitis, Serogroup B+1 more
University Ghent250 enrolled1 locationNCT06832514
Recruiting

Gynaecological Care for Transgender People in France in 2024.

Transgender Management Care
University Hospital, Bordeaux500 enrolled1 locationNCT06357130
Recruiting
Phase 4

Androgen Effects on the Reproductive Neuroendocrine Axis, 2025 Version

Reproductive IssuesTransgenderism
University of California, San Diego80 enrolled1 locationNCT07092527
Recruiting
Phase 2

Progesterone in Gender Affirming Hormone Therapy Study

Transgender Women
Emory University40 enrolled1 locationNCT06807580
Recruiting

Effects of Cross-sex Hormone Therapy on Eating Behavior, Metabolism, Energy Balance and Cardiovascular System

Arterial StiffnessAdiposityEating Behavior+3 more
University of Leipzig80 enrolled1 locationNCT04838249
Recruiting

Perception of Pain During Gender Affirming Hormone Therapy

Pain ThresholdTransgender PersonsPerception of Pain+1 more
Medical University of Vienna40 enrolled1 locationNCT07148921
Recruiting

Evaluating Sexual Functioning in Trans Men During the Gender Affirmation Process: A Mixed Methods Study

Sexual functioningGender affirmation surgeryTransgender Men
Eskisehir Osmangazi University52 enrolled1 locationNCT07131267
Recruiting
Not Applicable

TransHealthGUIDE: Transforming Health for Gender-Diverse Young Adults

(Gender) IdentityTransgender PersonsHealth Services for Transgender Persons
Boston Children's Hospital500 enrolled1 locationNCT06177600
Recruiting

Transgender Men, Non-binary Persons and Testosterone Treatment BODY IDENTITY CLINIC

Transgenderism
Marianne Andersen200 enrolled1 locationNCT04254354
Recruiting
Not Applicable

Prospective Imaging Assessment of Perineo-pelvic Static's Evolution After Sexual Reassignment Surgery in MtF Transgender Patient, by Peno-scrotal Inversion Vaginoplasty Technique (TRANSPELV)

Transgenderism
University Hospital, Limoges50 enrolled1 locationNCT06093724
Recruiting

Cervical and Endometrial Cancer Screening in Patients Seeking Gender-Affirming Hysterectomy

Cancer ScreeningTransgenderGender Diverse Populations
University of Minnesota40 enrolled1 locationNCT07075731
Recruiting

Puberty Suppression and Cardiometabolic Health

Insulin Sensitivity/ResistanceEndothelial DysfunctionVascular Stiffness+1 more
University of Colorado, Denver30 enrolled1 locationNCT04482374
Recruiting

Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth

Gender DysphoriaInsulin SensitivityTransgenderism
University of Colorado, Denver90 enrolled1 locationNCT04596592
Recruiting

Puberty, Testosterone, and Brain Development

(Gender) IdentityTransgenderHeadache+1 more
University of Colorado, Denver100 enrolled1 locationNCT06670053
Recruiting

Feminizing Treatment in Transgender Women and Non-binary Persons

Transgenderism
Odense University Hospital100 enrolled1 locationNCT05169762
Recruiting

New-onset Chronic Pelvic Pain in Transgender People Using Testosterone Therapy: an Exploratory Qualitative Study.

Pelvic PainTestosteroneTransgender Persons+1 more
University Hospital, Grenoble15 enrolled1 locationNCT06487754