Phase 1 Type 2 Diabetes Mellitus Clinical Trials
22 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 22 trials
Recruiting
Phase 1Phase 2
A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM
Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled20 locationsNCT06845202
Recruiting
Phase 1
Phase I Study to Evaluate the Pharmacokinetics and Safety After Co-administration of L03RD1 and L03RD2 or Administration of L03TD1 in Healthy Volunteers
Type 2 Diabetes Mellitus (T2DM)
Celltrion48 enrolled1 locationNCT07533539
Recruiting
Phase 1
A Study of REGEND003 on Patients With Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
Regend Therapeutics15 enrolled1 locationNCT07275788
Recruiting
Phase 1
A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or Obesity
ObesityOverweightType 2 Diabetes Mellitus
Hoffmann-La Roche30 enrolled1 locationNCT07137585
Recruiting
Phase 1
A Study to Evaluate the Effect of AZD6793 on the Pharmacokinetics and Pharmacodynamics of Metformin in Participants With Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus
AstraZeneca28 enrolled1 locationNCT07433062
Recruiting
Phase 1
A Study to Evaluate Pharmacokinetics of LY3209590 in Pediatric Participants With Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus
Eli Lilly and Company22 enrolled10 locationsNCT06362265
Recruiting
Phase 1
A Study to Evaluate the Effect of Fasting Duration and Dulaglutide (LY2189265) Withholding on Gastric Retention in Participants With Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus (T2DM)
Eli Lilly and Company20 enrolled1 locationNCT07313813
Recruiting
Phase 1
A Study to Evaluate the Effect of Maridebart Cafraglutide on Insulin Sensitivity and β-cell Function in Participants With Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus
Amgen70 enrolled1 locationNCT07160257
Recruiting
Phase 1
A phase 1 study to evaluate MWN109 injection in healthy subjects
ObesityType 2 Diabetes Mellitus
Shanghai Minwei Biotechnology Co., Ltd.72 enrolled1 locationACTRN12625000057482
Recruiting
Phase 1
A Phase 1b Study of QX1206 in T2DM Patients With NAFLD
Type 2 Diabetes Mellitus (T2DM)
1Globe Health Institute52 enrolled1 locationNCT06694935
Recruiting
Phase 1
Efficacy of Adipose Tissue Derived Stem Cells for the Treatment of Diabetic Foot Ulcers
Diabetes MellitusDiabetic Foot UlcerDiabetic Foot+8 more
University of the Punjab28 enrolled1 locationNCT05610865
Recruiting
Phase 1
A Randomised, Double-Blind, Placebo-Controlled, Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of MTS-201 in Healthy Volunteers and MTS-201 and Multiple Ascending Doses of MTS-201 in Combination with Sitagliptin in Obese, Otherwise Healthy Volunteers,
ObesityType 2 Diabetes Mellitus
METiS Pharmaceuticals Australia Pty Ltd80 enrolled1 locationACTRN12624001022550
Completed
Phase 1
A First-in-Human Phase 1 Study to evaluate the Safety and Tolerability of Single ascending doses of GSBR-1290 in Healthy Adult participants.
Type 2 Diabetes Mellitus
Gasherbrum Bio Pty Ltd. (Australian entity of ShouTi Inc)48 enrolled1 locationACTRN12622000084785
Completed
Phase 1
A Phase I, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of ALP001E in Healthy Subjects and Patients with Type 2 Diabetes
Type 2 Diabetes Mellitus
CMC Magnetics Corporation96 enrolled1 locationACTRN12620001214921
Completed
Phase 1
An Open-label Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Dapagliflozin 70 mg Extended Release Capsules in Healthy Volunteers
Type 2 Diabetes Mellitus
Novotech (Australia) Pty Limited10 enrolled1 locationACTRN12620001187932
Not Yet Recruiting
Phase 1
A Randomized, Double-blind, Placebo- controlled, Single Ascending Dose (SAD) Study of XW003 Injection in Healthy Adult Participants
Type 2 Diabetes MellitusNonalcoholic Steatohepatitis
Sciwind Biosciences APAC CO Pty. Ltd.50 enrolled1 locationACTRN12620000344998
Terminated
Phase 1
A Double-Blind, Randomized, Placebo-Controlled Phase I Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of CT-868 in Healthy Overweight/Obese Participants and in Patients with Type 2 Diabetes Mellitus
ObeseType 2 Diabetes Mellitus
Carmot Therapeutics103 enrolled3 locationsACTRN12618001988246
Completed
Phase 1
DCB-DM101 in Participants with Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus
VitNovo Australia Pty Ltd24 enrolled1 locationACTRN12618001140246
Completed
Phase 1
A randomised placebo controlled crossover trial to evaluate the effects of intrajejunal taurocholic acid on gastrointestinal hormone secretion and glycaemia in response to intrajejunal glucose infusion in healthy humans for the future design of treatments for type 2 diabetes mellitus
Designing future treatments for type 2 diabetes mellitus
Royal Adelaide Hospital14 enrolled1 locationACTRN12612001213831
Completed
Phase 1
A randomised placebo controlled crossover trial to evaluate the effects of different doses of taurocholic acid in an enema formulation on gastrointestinal hormone secretion and appetite in healthy humans for the future design of treatments for Type 2 diabetes mellitus and obesity
Designing future treatments for obesityDesigning future treatments for type 2 diabetes mellitus
Royal Adelaide Hospital12 enrolled1 locationACTRN12611000071921