Phase 1 Clinical Trials for Healthy Volunteers
First-in-human drug safety and dosing studies that compensate healthy adults.
There are 449 actively recruiting Phase 1 clinical trials enrolling healthy volunteers. Phase 1 studies test investigational drugs for safety and dosing in small groups under close medical supervision. Updated daily from ClinicalTrials.gov.
What is a Phase 1 trial?
Phase 1 is the first stage of human testing. A small group of healthy volunteers receives the investigational drug to evaluate safety, tolerability, and pharmacokinetics. Participants are monitored closely — often as inpatients at a clinical pharmacology unit — and compensated for their time. These studies are reviewed and approved by an ethics committee before enrollment begins.
Showing 401–420 of 449 Phase 1 studies
Tracing the Metabolic Flux of Orally Administered NAD+ Precursors
Study of SYH2062 Injection in Healthy Chinese Volunteers
Exploratory Clinical Study to Assess Safety and Efficacy of Xenon Gas Inhalation to Control Neuroinflammation
Classroom Break, Cognition, and Fitness in Elementary School Children
Pharmacokinetics of Y-4 Tablets With Pregabalin Capsules and Riluzole Tablets in Chinese Healthy Subject
Safety and Pharmacokinetics of Y-4 Tablets in Healthy Subjects
A Phase 1 Study of S-4321
Phase 1 Single Ascending Dose Study
A Study to Evaluate Safety and Pharmacokinetics of ZB002 in Healthy Participants and Participants With Rheumatoid Arthritis
Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy Participants
Safety and Pharmacokinetics of Extrato de Cannabis Sativa GreenCare
A Phase 1 Study of S-1117
Safety, Tolerability, and Pharmacokinetics of HL-003 in Healthy Subjects
Comparative Exercise-Induced Hypoalgesia in Upper and Lower Limbs: A Randomized Controlled Trial in Healthy Individuals
Impact of PEG Bowel Preparation on Gut Microbiome Composition Recovery
A Single and Multiple Ascending Dose Trial of LT-002-158 Tablets in Healthy Adult Volunteers
A Safety and Tolerability Study of BPR-30221616 Injection in Healthy Subjects
Pharmacokinetic Study of Oligonucleotides in Maixuekang Capsules
Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy Participants
Impact of OnabotulinumtoxinA (BOTOX®) on Stress
Phase 1 FAQ
How much do Phase 1 trials pay?
Compensation varies by study duration and intensity. Inpatient Phase 1 studies (multi-day residential stays) typically pay $1,000–$5,000+. Outpatient studies with follow-up visits may pay $200–$1,500. Specific amounts are disclosed in the informed consent document.
Are Phase 1 trials safe?
Phase 1 trials carry some risk as participants receive an investigational drug. All studies are reviewed and approved by an ethics committee (IRB/HREC) before enrollment begins. Participants are monitored continuously and can withdraw at any time.
What happens during a Phase 1 study?
Typically you attend a screening visit, then either stay at the clinical unit (inpatient) or visit regularly (outpatient). Blood draws, vital signs, and other assessments are conducted at scheduled intervals. The study team monitors you throughout and provides meals and accommodation for inpatient stays.