RecruitingACTRN12624001198516

Personalised Exercise Rehabilitation FOR people with Multimorbidity - The PERFORM-Aus trial

Effects of a Personalised Exercise Rehabilitation FOR people with Multimorbidity on hospitalisation compared to usual care: The PERFORM-Aus trial


Sponsor

Monash University

Enrollment

440 participants

Start Date

May 16, 2025

Study Type

Interventional

Conditions

Summary

This study aims to investigate the impact of Personalised Exercise Rehabilitation for people with Multimorbidity (PERFORM-Aus Trial) on hospitalisation compared with usual care. Who is it for? You may be eligible for this study if you are a male or female age 18 or older independently ambulant, diagnosis of two or more long-term health conditions, at least one of which has evidence of benefit from an exercise-based intervention. Study details Participants will be randomised to receive either PREFORM intervention or usual care. The PERFORM intervention involves an 8-week in-person supervised program at a rehabilitation centre, with sessions held twice weekly. Each session will last 2 hours and consist of one hour of exercise training (Move and Improve) and another hour focusing on patient self-care support and education (Health and Wellbeing sessions). After completion of the intervention, participants will be assessed for hospital admission, quality of life, exercise capacity, mental health, physical activity, treatment burden, fatigue, pain, breathlessness, adverse events and adherence. It is hoped that findings from this study will help manage these patients effectively with a multidisciplinary approach to address complex disease interactions.


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

People living with two or more long-term health conditions (multimorbidity) often find that healthcare is fragmented — each specialist focuses on one condition without considering the full picture. The PERFORM-Aus trial is testing whether a personalised, multidisciplinary exercise rehabilitation program reduces hospital admissions and improves quality of life in this group, compared to receiving usual care. Participants will be randomly assigned to either attend the 8-week PERFORM program (twice-weekly sessions with exercise training and self-care education) or continue with their usual healthcare. Hospital admissions, quality of life, exercise capacity, and mental health will be tracked over time. You may be eligible if you are 18 or older, can walk independently, and have been diagnosed with two or more long-term conditions — including things like arthritis, diabetes, depression, chronic kidney disease, Parkinson's disease, or stroke. People who cannot attend in-person sessions, have active cancer under treatment, are pregnant, or live in residential aged care are not eligible. This study aims to provide a more holistic approach to managing complex, ongoing health challenges.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Participants randomised to the PERFORM intervention will undergo an 8-week in-person supervised program at a rehabilitation centre, with sessions held twice weekly. Each session will last 2 hours and

Participants randomised to the PERFORM intervention will undergo an 8-week in-person supervised program at a rehabilitation centre, with sessions held twice weekly. Each session will last 2 hours and consist of one hour of exercise training (Move and Improve) and another hour focusing on patient self-care support and education (Health and Wellbeing sessions). Staff will receive at least 4 hours of training in delivery of the PERFORM intervention, delivered in hybrid format (F2F and online), prior to enrolling the first participant. Move and Improve: The exercise program will be based on the American College of Sports Medicine's guideline (Exercise management for persons with chronic diseases and disabilities). It will be supervised by seasoned physiotherapists/exercise physiologists. The exercise program will feature personalized and progressive aerobic and resistance training. Aerobic training will consist of walking (treadmill or corridor) and cycle training for up to 30 minutes in a moderate intensity (Borg RPE scale rates exertion between 12 to 14 or Borg breathlessness scale, range 3-4). The resistance training will consist of lower limb and upper limb dumbbell exercises prescribed as tolerated to achieve 2–3 sets of 10 – 15 repetitions of each exercise. Participants will receive a comprehensive exercise booklet and a standardized progress-tracking diary to encourage their involvement in a home exercise routine. In the progress-tracking diary, participants will document exercise frequency, duration, and post-exercise symptom evaluations for aerobic and resistance training. The fidelity of Move and Improve component will involve three steps: - Staff Training: The Move and Improvement program staff will undergo training to ensure that everyone will adhere to the intervention protocol. Regular supervision and refresher training will help maintain consistency. - Audit of Exercise Prescription and Progression: Periodic audits of exercise prescription records and progression will be carried out to ensure that the exercise plan is being implemented as intended. This includes confirming that the exercises, intensity, duration and frequency align with the study protocol. - Assessment of Participant Engagement: This will involve tracking attendance, adherence to prescribed exercises, and completion of the exercise booklet for the home exercise program. Health and Wellbeing sessions: The health and wellbeing (H&WB) sessions will be delivered in a group of participants by a healthcare professional trained by experienced behaviour change personnel. The H&WB will be grounded in behaviour change to support positive lifestyle modifications and symptom management. In total, 16 topics will be delivered throughout the eight weeks (one topic per session). The chosen topics are broad to embrace multiple health aspects which are potentially shared by people with multimorbidity covering healthy diet (two sessions), physical activity, exercise, sleep, stress, relaxation, energy, pain management, respiratory symptom management, mood management, how to cope multiple health conditions, medicines adherence, principle and strategies for changing behaviour, and habit formation. Additionally, written leaflets and materials will be provided to support participants to share information with their families and caregivers. The resources (exercise booklet and leaflets) were developed by the University of Leicester and adapted for the Australian context. For the fidelity assessment for the Health & Wellbeing component, all sessions will be recorded over a one-month period at two specific times: 6 months and 18 months at all sites. From these recorded sessions, a random selection will be made for the fidelity assessment.


Locations(8)

The Alfred - Melbourne

NSW,QLD,SA,VIC, Australia

Austin Health - Austin Hospital - Heidelberg

NSW,QLD,SA,VIC, Australia

Royal Brisbane & Womens Hospital - Herston

NSW,QLD,SA,VIC, Australia

The Royal Adelaide Hospital - Adelaide

NSW,QLD,SA,VIC, Australia

Mt Wilga Private Hospital - Hornsby

NSW,QLD,SA,VIC, Australia

The Queen Elizabeth Hospital - Woodville

NSW,QLD,SA,VIC, Australia

Frankston Hospital - Frankston

NSW,QLD,SA,VIC, Australia

United Kingdom

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ACTRN12624001198516


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