PPA Clinical Trials

16 recruitingLast updated: May 21, 2026

There are 16 actively recruiting ppa clinical trials across 7 countries. Studies span Not Applicable, Phase 2, Phase 4. Top locations include Rochester, Minnesota, United States, San Francisco, California, United States, Boston, Massachusetts, United States. Updated daily from ClinicalTrials.gov.


PPA Trials at a Glance

16 actively recruiting trials for ppa are listed on ClinicalTrialsFinder across 6 cities in 7 countries. The largest study group is Not Applicable with 8 trials, with the heaviest enrollment activity in Rochester, San Francisco, and Boston. Lead sponsors running ppa studies include Boston Children's Hospital, Maya Henry, and Mayo Clinic.

Browse ppa trials by phase

About PPA Clinical Trials

Looking for clinical trials for PPA? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new PPA trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about PPA clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 116 of 16 trials

Recruiting
Not Applicable

Remotely-supervised Neuromodulation in PPA

Primary Progressive Aphasia(PPA)Progressive AphasiaProgressive Aphasia in Alzheimer's Disease+3 more
Maya Henry80 enrolled2 locationsNCT07260253
Recruiting
Phase 2

Clinical Study of Neflamapimod in Patients With Primary Progressive Aphasia

Nonfluent Variant Primary Progressive Aphasia (nfvPPA)
EIP Pharma Inc20 enrolled7 locationsNCT07033481
Recruiting
Not Applicable

Long Term Effect of Brain Stimulation in PPA

Primary Progressive Aphasia(PPA)
Hospital San Carlos, Madrid80 enrolled1 locationNCT07158216
Recruiting
Not Applicable

Intervention for Communication Quality of Life in Primary Progressive Aphasia

Primary Progressive Aphasia(PPA)Progressive AphasiaLogopenic Progressive Aphasia (LPA)+9 more
Maya Henry30 enrolled1 locationNCT07219680
Recruiting
Not Applicable

Personalized Perioperative Analgesia Platform (PPAP) for Pediatric Spine Fusion Surgery (sIRB)

Spine FusionPPAP
Senthil Sadhasivam300 enrolled5 locationsNCT05367609
Recruiting
Not Applicable

Effect of Thickened Feeds on Swallow Physiology in Children With Dysphagia

AspirationDysphagiaBrief Resolved Unexplained Event (BRUE)+1 more
Boston Children's Hospital200 enrolled1 locationNCT04504227
Recruiting

Effect of Thickened Feeds on Clinical Outcomes in Children With Brief Resolved Unexplained Event

Oropharyngeal DysphagiaBrief Resolved Unexplained EventApparent Life Threatening Event
Boston Children's Hospital250 enrolled1 locationNCT04477460
Recruiting

Speech and Language Interventions for Italian People With PPA

Primary Progressive Aphasia(PPA)
Istituti Clinici Scientifici Maugeri SpA30 enrolled2 locationsNCT06739967
Recruiting

UPenn Observational Research Repository on Neurodegenerative Disease

Corticobasal Syndrome(CBS)Progressive Supranuclear Palsy (PSP)Primary Progressive Aphasia(PPA)+6 more
University of Pennsylvania1,000 enrolled1 locationNCT04715399
Recruiting
Not Applicable

Repetitive Transcranial Magnetic Stimulation in Frontotemporal Lobar Degeneration

PSPFTDrTMS+5 more
Università degli Studi di Brescia120 enrolled1 locationNCT07316413
Recruiting
Not Applicable

Rapid Management of Resistant Hypertension in the Public Health System (Fast Control)

HypertensionHigh Blood PressureApparent Resistant Hypertension
Instituto Dante Pazzanese de Cardiologia142 enrolled1 locationNCT07259733
Recruiting
Phase 4

Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech

Apraxia of SpeechPrimary Progressive AphasiaPPA+2 more
Mayo Clinic50 enrolled1 locationNCT01818661
Recruiting
Not Applicable

STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners

Caregiver BurdenCorticobasal SyndromePrimary Progressive Aphasia(PPA)+1 more
Oregon Health and Science University640 enrolled1 locationNCT06613204
Recruiting

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

Amyotrophic Lateral SclerosisCorticobasal Degeneration (CBD)Progressive Supranuclear Palsy (PSP)+11 more
Mayo Clinic2,100 enrolled27 locationsNCT04363684
Recruiting
Phase 2

Nabilone for Agitation in Frontotemporal Dementia

Frontotemporal DementiaPrimary Progressive AphasiaFTD+3 more
Simon Ducharme, MD45 enrolled7 locationsNCT05742698
Recruiting

Evaluating response to exercise programs in monozygotic and dizygotic twins to determine whether exercise response is generic, genetic or modality dependent.

Cardiovascular health responses to exercise modalities in apparently healthy subjects
Winthrop Professor Daniel Green100 enrolled1 locationACTRN12616001095459