Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases

This trial is comparing two approaches to focused brain radiation (stereotactic radiosurgery, or SRS) for people with cancer that has spread to the brain and needs surgery: giving the radiation before the operation versus giving it after. **You may be eligible if...** - You have cancer that has spread to the brain (brain metastasis) and surgery to remove it is planned - Your brain tumor is up to 4 cm (or up to 7 cm for a multi-dose radiation approach) - You are a good surgical candidate - Your overall health is reasonably good (Karnofsky ≥ 70 or ECOG ≤ 2) - You are 18 years or older **You may NOT be eligible if...** - Your cancer has spread throughout the lining of the brain (leptomeningeal disease) - You have more than the allowed number of brain tumors for this study - Your overall health is too poor for surgery or radiation - You have certain implants that prevent MRI scanning Talk to your doctor to see if this trial is right for you.