Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient

This study aims to build a database of brain monitoring data from elderly patients undergoing non-cardiac surgeries under general anesthesia to better understand and predict post-operative cognitive changes. Older adults are at higher risk of cognitive decline after surgery — including memory issues and confusion — and this study seeks to identify brain activity patterns that can predict who is most at risk, paving the way for 'precision anesthesia' tailored to individual patients. Participants aged 65 and older who are undergoing elective non-cardiac general surgery expected to last at least 2 hours will have their brain activity (EEG) monitored during the procedure. Cognitive assessments will be done before and after surgery. You may be eligible if: - You are 65 years of age or older - You are scheduled for non-cardiac elective surgery - Your surgery is expected to require general anesthesia for at least 2 hours You may NOT be eligible if: - You have a diagnosis of Alzheimer's disease or dementia - You have Parkinson's disease - You have a history of other neurodegenerative disease - You are currently taking benzodiazepines for depression - You have a history of alcoholism Talk to your doctor to see if this trial is right for you.