RecruitingNCT04190849

European Paediatric Non-Alcoholic Fatty Liver Disease Registry (EU-PNAFLD)

The European Paediatric Non-alcoholic Fatty Liver Disease Registry (EU-PNAFLD): a Prospective, Longitudinal Follow-up of Children With Non-alcoholic Fatty Liver Disease

Sponsor

Cambridge University Hospitals NHS Foundation Trust

Enrollment

2,000 participants

Start Date

Nov 14, 2017

Study Type

OBSERVATIONAL

Conditions

Non-Alcoholic Fatty Liver Disease Non Alcoholic Steatohepatitis Non-alcoholic Fatty Liver

Summary

The EU-PNAFLD (The European Paediatric NALFD Registry) will be a network composed of European centres involved in the care of children with NAFLD, and will include Hepatologists, Endocrinologists, and Scientists, supported by relevant international specialists. This collaboration will build on existing infrastructure (local databases and bio-repositories) and will align with the adult European NAFLD Registry ("EPoS", Elucidating Pathways of Steatohepatitis study) to allow long-term follow-up supported by translational studies. Through an international, well-characterised large-scale cohort, we hope to: facilitate multi-centre clinical trials; extend our understanding of the key disease mechanisms of NAFLD; and establish the natural history of paediatric NAFLD.

Eligibility

Max Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is a registry study tracking children and adolescents in Europe with non-alcoholic fatty liver disease (NAFLD) — a condition where excess fat builds up in the liver, not caused by alcohol. The goal is to understand how the disease progresses over time and how it responds to treatment. **You may be eligible if...** - You were diagnosed with NAFLD before age 18 - Your diagnosis was confirmed by imaging (e.g., ultrasound) or liver biopsy - Other causes of liver disease have been ruled out (e.g., viral hepatitis, autoimmune disease) **You may NOT be eligible if...** - Your liver disease is caused by a different condition (alcohol, viral hepatitis, medication, genetic liver disease, etc.) - You do not have documented evidence of hepatic steatosis (fat in the liver) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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