RecruitingNCT04442334

The European NAFLD Registry

Sponsor

Newcastle University

Enrollment

10,000 participants

Start Date

May 1, 2015

Study Type

OBSERVATIONAL

Conditions

Hepatocellular Carcinoma Obesity Cardiovascular Diseases Hypertension Type 2 Diabetes Fibrosis, Liver NAFLD NASH NASH - Nonalcoholic Steatohepatitis Steatosis of Liver Dyslipidaemia Other Associated Comorbidities

Summary

The European NAFLD Registry is a prospectively recruited, observational study supporting the study of the clinical phenotype, natural history, disease outcomes and pathophysiology of Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis. The ultimate goals are to better understand the drivers of interpatient variation in disease pathophysiology and severity and to utilise this information to develop and validate biomarkers that, singly or in combination, enable detection and monitoring of disease progression and/or from NAFL through NASH to fibrosis and cirrhosis.

Eligibility

Min Age: 18 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study is building a large registry (database) to track people with non-alcoholic fatty liver disease (NAFLD) — now often called metabolic-associated fatty liver disease — over time to better understand how the disease progresses. **You may be eligible if...** - You are 18 or older - You have been diagnosed with or are suspected of having fatty liver disease (NAFLD/NASH), confirmed or suspected through a liver biopsy or imaging scan **You may NOT be eligible if...** - Your liver disease is caused by alcohol, viral hepatitis, or another specific cause other than metabolic/fatty liver disease - You are unable to provide informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(37)

Universitair Ziekenhuis Antwerpen

Antwerp, Belgium

Helsinki University Hospital

Helsinki, Finland

Le Centre de Recherche Clinique (CRC) du CHU d'Angers

Angers, France

Institut ICAN - Institute of Cardiometabolism And Nutrition Hôpital de la Pitié Salpêtrière

Paris, France

UNIVERSITÄTSKLINIKUM der RWTH Aachen

Aachen, Germany

Charité University Hospital Berlin

Berlin, Germany

Universitätsklinikum Freiburg

Freiburg im Breisgau, Germany

UNIVERSITÄTSMEDIZIN der Johannes Gutenberg Universität Mainz

Mainz, Germany

Universitätsklinikums Würzburg

Würzburg, Germany

Laiko General Hospital of Athens

Athens, Greece

Polytechnic University of Marche

Ancona, Italy

Università degli Studi Milano

Milan, Italy

Università di Palermo

Palermo, Italy

Università Cattolica del Sacro Cuore

Rome, Italy

Department of Medical Sciences University of Torino

Turin, Italy

Amsterdam UMC

Amsterdam, Netherlands

Hospital de Santa Maria

Lisbon, Portugal

Vall d'Hebron University Hospital

Barcelona, Spain

Biodonostia Health Research Institute

Donostia / San Sebastian, Spain

Puerta de Hierro University Hospital

Majadahonda, Spain

Marqués de Valdecilla University Hospital

Santander, Spain

Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocío University Hospital

Seville, Spain

HU Clínico de Valladolid

Valladolid, Spain

Karolinska Universitetssjukhuset

Huddinge, Sweden

Linköping University Hospital

Linköping, Sweden

Inselspital, University Hospital

Bern, Switzerland

University Hospitals Birmingham Nhs Foundation Trust

Birmingham, United Kingdom

Addenbrooke'S Hospital

Cambridge, United Kingdom

Queen Elizabeth Hospital

Gateshead, United Kingdom

Hull Royal Infirmary

Hull, United Kingdom

Royal London Hospital, Barts Health NHS Trust

London, United Kingdom

St George's University Hospitals

London, United Kingdom

The Newcastle Upon Tyne Hospitals Nhs Foundation Trust

Newcastle upon Tyne, United Kingdom

Queen'S Medical Centre

Nottingham, United Kingdom

Oxford University Hospitals Nhs Foundation Trust

Oxford, United Kingdom

Derriford Hospital

Plymouth, United Kingdom

Queen Alexandra Hospital

Portsmouth, United Kingdom

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