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RecruitingNot ApplicableNCT04475640

Cancer Genetic Testing in Ethnic Populations

GEMINI - Cancer Genetic Testing in Ethnic Populations

Sponsor

Mayo Clinic

Enrollment

1,800 participants

Start Date

Jan 13, 2020

Study Type

INTERVENTIONAL

Conditions

Breast CarcinomaHead and Neck CarcinomaMalignant Brain NeoplasmMalignant Solid NeoplasmSkin CarcinomaCarcinoma of Unknown PrimaryCentral Nervous System CarcinomaDigestive System CarcinomaGenitourinary System CarcinomaMalignant Female Reproductive System NeoplasmMalignant Musculoskeletal Neoplasm

Summary

This clinical trial examines the integration of cancer genetic testing in various ethnic populations. Studying individuals and families at risk of cancer may help identify cancer genes and other persons at risk. The information from this study may provide an opportunity for cancer risk stratification and individualized screening in these ethnic populations.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

  • Patients at least 18 years of age
  • Individuals diagnosed with any solid tumor cancer including, but not limited to, gastrointestinal, breast, gynecological, genitourinary, skin, central nervous system (CNS)/brain, head/neck, musculoskeletal or cancer of unknown primary; and presenting to Mayo Clinic (MC Arizona or MC Florida) for clinical management/treatment; and patients receive genetic testing as described above
  • Self-identified as being from various ethnic populations including Hispanic/Latino, Native American/Alaskan, African American (including of African descent), Asian and other European populations
  • Blood collection is feasible (health, access and/or tolerability) for requested blood sample(s)
  • Individuals have agreed to participate and signed the study informed consent form

Exclusion Criteria3

  • Patients who have had prior germline genetic testing involving a 40+ gene panel within the last 24 months at Mayo Clinic and available for review by the research coordinator at time of consent
  • Past or current history of hematological cancer (including leukemias, multiple myeloma)
  • All bone marrow transplants

Interventions

PROCEDUREBiospecimen Collection

Undergo collection of blood sample

OTHERGenetic Testing

Undergo genetic testing

Locations(2)

Mayo Clinic in Arizona

Scottsdale, Arizona, United States

Mayo Clinic in Florida

Jacksonville, Florida, United States

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NCT04475640

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