RecruitingNot ApplicableNCT04498221

Lymphatic Mapping Of Oropharyngeal Cancer

Prospective, Multi-Centre, Phase II Validation Study for a Lymphatic Imaging Protocol in Establishing Drainage Patterns in Patients With Oropharyngeal Cancer


Sponsor

University College, London

Enrollment

150 participants

Start Date

Jul 7, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

A multi-centre validation study to evaluate whether a new imaging and surgical protocol would work as well as the current gold standard in identifying sentinel nodes in patients with oropharyngeal cancer.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new imaging technique to map the lymph nodes involved in throat cancer (specifically oropharyngeal cancer). The goal is to find more precise ways to target only the affected lymph nodes, potentially reducing side effects from treatment. **You may be eligible if...** - You are 18 or older - You have a new diagnosis of oropharyngeal cancer (cancer of the throat/tonsil area) - Your cancer has spread to lymph nodes on only one side of the neck - You are scheduled for surgery or radiation treatment **You may NOT be eligible if...** - There is suspected cancer spread to lymph nodes on both sides of your neck - You have had prior treatment for head and neck cancer - You are pregnant - You have certain allergies to imaging agents Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREImaging procedure

During routine examination under anaesthetic 4 x peritumoural injection of investigator's choice of 99mTc-human albumin colloidal particles or Lymphoseek (lymphatic mapping tracer) followed by freehand SPECT scan

PROCEDURESurgical procedure

Excision of contralateral nodes identified on imaging \*(fhSPECT or SPECT/CT\*) during routine examination under anaesthetic. Serial sectioning of excised (sentinel) nodes to identify micrometastasis.


Locations(2)

St George's University Hospitals NHS Foundation Trust

London, United Kingdom

University College Hospital

London, United Kingdom

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NCT04498221


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