RecruitingNCT04625569

Genetic of Response to Acute Saline Load Test in Hypertension (Naload)

Role of Genetic Determinants in the Response to Acute Saline Load Testing in Patients With Essential Hypertension (Naload)

Sponsor

Ospedale San Raffaele

Enrollment

150 participants

Start Date

Jul 8, 2019

Study Type

OBSERVATIONAL

Conditions

Genetic Predisposition to Disease Hypertension,Essential Salt; Excess Genetic Hypertension

Summary

NHP referred to our outpatient clinic will be enrolled (150 newly recruited) in acute saline test for phenotype characterisation of PNat relationship(7). For each patient we will collect urine and blood samples for standard clinical biochemistry, including electrolytes, creatinine, EO, aldosterone, plasma renin activity, urinary uromodulin (ELISA), urinary and serum uric acid and blood samples for genetic test.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria3

age 18 to 65years;
body mass index (BMI) \<30 kg/m2;
Na intake, evaluated as urinary Na excretion of \<300 mEq/24 hours; .office systolic BP (SBP) \>140 mm Hg and diastolic BP (DBP) \>90 mm Hg in 3 consecutive visits to their family doctors.

Exclusion Criteria9

Female patients
history of myocardial infarction,
stroke,
congestive heart failure,
liver disease, secondary cause of hypertension,
diabetes,
severe hypertension (\>160/110 mm Hg),
abuse of drugs or alcohol, .creatinine clearance \< 80 mL/m.
Secondary forms of hypertension (e.g. primary aldosteronism) were ruled out with specific investigations when deemed appropriate