CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease

This study is looking at whether a combination of coenzyme Q10 (CoQ10) supplements and exercise can help treat mitochondrial dysfunction — essentially, poor energy production in cells — in people with advanced kidney disease on dialysis. **You may be eligible if:** - You are between 18 and 75 years old - You have end-stage kidney disease and have been on hemodialysis three times a week for at least 6 months - Your dialysis is working well (adequate clearance levels) - You are otherwise clinically stable **You may NOT be eligible if:** - Your BMI is over 35 - You had a kidney transplant in the past 6 months - You are taking immunosuppressant medications - You have an active infection or connective tissue disease - You recently had a heart attack or stroke (within 3 months) - You have uncontrolled blood pressure, abnormal heart rhythms, or chest pain at rest - Your heart pumping function is below 30% - You have active cancer (other than minor skin cancer) - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.