RecruitingNot ApplicableNCT05477901

Impacts of Cash Transfers on Child Neurodevelopment (Auxilio Brasil)

Mental Health and Bolsa Familia: A Mechanistically Focused Clinical Trial of a Cash Transfer Intervention on Child Brain, Behavior, and Mental Health


Sponsor

New York State Psychiatric Institute

Enrollment

450 participants

Start Date

May 28, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study examines the impact of Auxilio Brasil (AB), a cash transfer program to mothers of school-age children, on resource-deprived populations in Brazil and its protective effects on child neurodevelopment and mental health. The investigators will conduct a randomized clinical trial (RCT) among those already receiving AB in which 300 families will be randomized in a 1:1 ratio to receive either a high ($40/month) or low ($2/month) supplemental transfer for 2 years. Three hundred children (index child participants; 7-10 years old) will be enrolled across both study arms. Additionally, up to 150 siblings ("sibling participants;" 7-10 years old) will be enrolled. Eligible families who decide to participate will sign a study-specific informed consent (mother) and assent (child) form. The UNIFESP team will conduct the respective assessments at baseline, approximately 8- and 16- months, 24-months and approximately 6-months post-RCT. Aim 1: Determine the impact of high vs low cash transfers on children's exposure to adversities (ACEs) and neurodevelopment. Aim 2: Determine the impact of cash transfers on children's inflammatory markers and HPA activity/cortisol. Exploratory Aim: The investigators will explore (i) whether sex/gender of the children moderates the pathways in the above mediation model; and (ii) whether cash transfer-related effects persist 6 months post-RCT.


Eligibility

Min Age: 23 YearsMax Age: 45 Years

Inclusion Criteria5

  • Mother:
  • Age 23-45 years old
  • Receiving AB cash transfers
  • Has at least two or more children ages 7- 10 years old at time of recruitment (up to 4 children per family)
  • Able to consent

Exclusion Criteria10

  • \. Mother and child do not reside in same household
  • Child:
  • Inclusion Criterion
  • Age 7-10 years old
  • Intellectual Disability
  • Exclusion Criterion
  • Does not reside in same household as the mother
  • Major Axis I disorder (e.g., Autism, Schizophrenia, Bipolar)
  • Severe Disability
  • MRI contradictions (index child only)

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Interventions

OTHERSupplemental cash transfer

Supplemental cash transfer ($40/month)


Locations(2)

New York State Psychiatric Institute

New York, New York, United States

UNIFESP

São Paulo, São Paulo, Brazil

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NCT05477901


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