RecruitingNCT05638269

A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China

Sponsor

Zhujiang Hospital

Enrollment

12,000 participants

Start Date

Mar 1, 2022

Study Type

OBSERVATIONAL

Conditions

Liver Cancer Pancreatic Cancer Gastric Cancer Lung Cancer Nasopharyngeal Cancer Chronic Kidney Diseases Epilepsy Essential Hypertension Acute Coronary Syndrome Primary Aldosteronism Subclinical hypothyroïdism

Summary

The human gut microbiome has been associated with many health factors but variability between studies limits the exploration of effects between them. This study aims to systematically characterize the gut microbiota of various critical chronic diseases, compare the similarities and differences of the microbiome signatures linked to different regions and diseases, and further investigate their impacts on microbiota-based diagnostic models.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This large Chinese study collects stool and other samples from patients with serious chronic conditions — such as diabetes, heart disease, or kidney disease — to examine how their gut bacteria (microbiome) differ from healthy people. This is observational research, not a treatment trial. **You may be eligible if...** - You are between 18 and 75 years old - You have been medically diagnosed with one of the study's target chronic diseases - You have lived in the local province for the past 3 years - You are willing to provide written consent **You may NOT be eligible if...** - You have other serious illnesses that could confound the data - You are pregnant or breastfeeding (unless specifically in the pregnancy group) - You have taken antibiotics recently, which can alter gut bacteria Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERno intervention

Observational studies, no intervention

Locations(50)

Emergency General Hospital

Chaoyang, Beijing Municipality, China

The People's Hospital Of Nanchuan Chongqing

Nanchuan, Chongqing Municipality, China

YongChuan hospital of Chongqing Medical Univeristy

Yongchuan, Chongqing Municipality, China

Fujian Medical University Union Hospital

Fuzhou, Fujian, China

Fujian Provincial Hospital

Fuzhou, Fujian, China

Fujian Cancer Hospital

Fuzhou, Fujian, China

The First Hospital of Lanzhou University

Lanzhou, Gansu, China

Lanzhou University Second Hospital

Lanzhou, Gansu, China

The Sixth Affiliated Hospital of South China University of Technology (Foshan Nanhai District People's Hospital )

Foshan, Guangdong, China

The First Affiliated Hospital of Jinan University（Guangzhou Overseas Chinese Hospital ）

Guangzhou, Guangdong, China

The seventh Affiliated Hospital, Sun Yat-sen University

Shenzhen, Guangdong, China

Zhongshan City People's Hospital

Zhongshan, Guangdong, China

The Second Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, China

People's Hospital of Guangxi Zhuang Autonomous Region

Nanning, Guangxi, China

Wuzhou Red Cross Hospital

Tongliao, Guangxi, China

The Affiliated Cancer Hospital of Guizhou Medical University

Guiyang, Guizhou, China

The Affiliated Hospital of Guizhou Medical University

Guiyang, Guizhou, China

Hainan Traditional Chinese Medicine Hospital

Haikou, Hainan, China

Daqing People's Hospital（The Fifth Affiliated Hospital of Harbin Medical University）

Daqing, Heilongjiang, China

The First Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China

The Sixth Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China

Jixi Ji Mine Hospital

Jixi, Heilongjiang, China

Qiqihar Hospital of Traditional Chinese Medicine

Qiqihar, Heilongjiang, China

Luoyang Maternal and Child Health Hospital

Luoyang, Henan, China

Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine,Medical College of Henan University of Science and Technology

Luoyang, Henan, China

Shangqiu First People's Hospital

Shangqiu, Henan, China

Wuhan Mental Health Center

Wuhan, Hubei, China

Xiangyang Central Hospital

Xiangyang, Hubei, China

Nanzhang People's Hospital

Xianyang, Hubei, China

Zhuzhou Central Hospital

Zhuzhou, Hunan, China

Affiliated Hospital of Inner Mongolia Minzu University

Wuzhou, Inner Mongolia, China

Wuxi No.2 People's Hospital

Wuxi, Jiangsu, China

Affiliated Hospital of Jinggangshan University

Ji’an, Jiangxi, China

First Affiliated Hospital of Gannan Medical University

Ganzhou, Jiangx, China

The Second Affiliated Hospital of Nanchang University

Nanchang, Jiangx, China

Chang Zhi Yi Xue Yuan Fu Shu He Ji Yi Yuan

Changzhi, Shanxi, China

The Second Hospital of Shanxi Medical University

Taiyuan, Shanxi, China

The Hospital of Shanxi University of Chinese Medicine

Taiyuan, Shanxi, China

Xi'an People's Hospital (Xi'an Fourth Hospital)

Xi’an, Shanxi, China

The First Affiliated Hospital of Xi'an Medical University

Xi’an, Shanxi, China

The General Hospital of Western Theater Command PLA

Chengdu, Sichuan, China

Guang'an People's Hospital

Guang’an, Sichuan, China

The People's Hospital of Leshan

Leshan, Sichuan, China

Tianjin Binhai New Area Dagang Hospital

Binhai, Tianjin Municipality, China

Tianjing Medical University Cancer Institute & Hospital

Dayingmen, Tianjin Municipality, China

Tianjin Beichen Hospital

Guoyuan Xincun, Tianjin Municipality, China

The First People's Hospital of Kashgar Prefecture

Kashgar, Xinjiang Uygur Autonomous Region, China

First Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, China

Qunjing Hospital of Traditional Chinese Medicine

Qujing, Yunnan, China

Hwa Mei Hospital,University of Chinese Academy of Sciences

Ningbo, Zhejiang, China

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NCT05638269

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