Safety and Efficacy of Empagliflozin in Hemodialysis

This study is testing whether a diabetes medication called empagliflozin (commonly used for blood sugar and heart health) is safe and helpful for people on regular dialysis who still produce some urine. Researchers want to know if it can improve outcomes for dialysis patients with remaining kidney function. **You may be eligible if...** - You are 18 or older and on maintenance hemodialysis (dialysis 3 times per week) - You still produce some urine (at least 200 mL per day) - You are willing and able to give informed consent **You may NOT be eligible if...** - You produce very little to no urine - You are scheduled for a kidney transplant within 3 months - You have had more than 2 urinary tract infections per year - You have severe heart failure (Class IV) or recently had a heart attack or stroke - You have Type 1 diabetes or a history of diabetic ketoacidosis - You have active cancer being treated with chemotherapy or radiation - You recently had major surgery or an amputation - You have significant liver disease Talk to your doctor to see if this trial is right for you.