RecruitingNot ApplicableNCT05886114

A Multi-domain Lifestyle Intervention Among Aged Community-residents in Zhejiang, China

Sponsor

Zhejiang University

Enrollment

1,200 participants

Start Date

May 28, 2023

Study Type

INTERVENTIONAL

Conditions

Cognitive Impairment Brain Diseases Central Nervous System Diseases Alzheimer Disease Nervous System Diseases Cognition Disorder Neurocognitive Disorders Mental Disorder Vascular Cognitive Impairment Dement

Summary

A study conducted in Finland discovered that a multidomain intervention, consisting of physical activity, nutritional guidance, cognitive training, social activities, and management of vascular risk factors, effectively decelerated cognitive decline in healthy older adults who were at an increased risk of cognitive decline. The HERITAGE study is a 2-year clustered randomized controlled trial (clustered-RCT) that explores the efficacy of a multidomain intervention among 1200 elderly residents with a higher risk of cognitive decline and dementia in Zhejiang Province, China

Eligibility

Min Age: 60 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a multi-component lifestyle program — including exercise, nutrition, cognitive training, and social activities — to see if it can slow cognitive decline in older adults who are at risk for developing dementia. **You may be eligible if...** - You are an older adult living in the community in Zhejiang, China - You show early signs of cognitive risk (some memory or thinking concerns, but no dementia diagnosis) - You have no physical disabilities that prevent you from participating in lifestyle activities - You are willing to participate for 24 months and be randomly assigned to either the intervention or control group **You may NOT be eligible if...** - You have been diagnosed with dementia - You have major depression or another serious neuropsychological condition - You have cancer or active cardiovascular disease - You have undergone a revascularization procedure within the past year - You have severe loss of vision, hearing, or speech Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALStructured Multi-domain Intervention

Structured Multi-domain Intervention (SMI) involves providing participants with intensive structure and support by a team of trainers to increase physical exercise, adhere to a healthy diet, cognitive training, increase intellectual/social stimulation, and better manage vascular risk factors.

BEHAVIORALSelf-Guided Intervention

In the Self-Guided Intervention (SGI), education about the importance of a healthy lifestyle as a preventive strategy and support to encourage change will be provided.

Locations(1)

School of Public Health and The Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, China

Hangzhou, Zhejiang, China

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NCT05886114

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