Diaphragmatic Function as a Biomarker
Diaphragmatic Function as a Biomarker in Patients With Respiratory Diseases
RWTH Aachen University
800 participants
Jul 1, 2023
OBSERVATIONAL
Conditions
Summary
Dyspnea is among the most common symptoms in patients with respiratory diseases such as Asthma, chronic obstructive pulmonary disease (COPD), Fibrosis, and Pulmonary Hypertension. However, the pathophysiology and underlying mechanisms of dyspnea in patients with respiratory diseases are still poorly understood. Diaphragm dysfunction might be highly prevalent in patients with dyspnea and respiratory diseases. The association of diaphragm function and potential prognostic significance in patients with respiratory diseases has not yet been investigated.
Eligibility
Inclusion Criteria5
- patient has one of the following lung diseases: COPD, bronchial asthma, pulmonary fibrosis, pulmonary hypertension
- is 18 years or older
- is mentally and physically able to understand the study and to follow instructions
- are legally competent
- signed declaration of consent
Exclusion Criteria10
- BMI \> 35
- current or treatments or diseases in the past which could influence the evaluation of the study
- Expected lack of willingness to actively participate in study-related measures
- alcohol or drug abuse
- disc herniation/prolapse
- epilepsy
- wheelchair bound
- in custody due to an official or court order
- in a dependent relationship or employment relationship with investigating physician or one of their deputy
- emergency inpatient hospital stay within 4 weeks before study-specific examinations
Interventions
Ultrasound of the Diaphragm at the end of inspiration and expiration
Ultrasound of the Intercostal Muscles at the end of inspiration and expiration
Questionnaire for Perceived Exertion (Borg Rating of Perceived Exertion Scale)
The MRC Dyspnoea Scale allows the patients to indicate the extent to which their breathlessness affects their mobility.
Specialized respiratory questionnaire with different domains (Emotional Domain, Dyspnea Domain, Mastery Domain, Fatigue Domain)
Patients are classified according to the GINA classification of Asthma.
Inspiratory and expiratory Measurement of respiratory mouth pressure
Measurement of Sniff Nasal Inspiratory Pressure
The maximum walking distance achieved in 6 minutes
number of repetitions achieved in sitting down and standing up in 60 seconds
electromyography of the muscles of respiration via superficial electrodes
Measurement of lung function via body plethysmography
COPD Assessment Test (CAT)
Patients with pulmonary hypertension are classified according to the ESC/ERS risk group.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05903001