RecruitingNot ApplicableNCT05976165

A Study of Breath Testing for Small Intestinal Bacterial Overgrowth

Breath Testing for Small Intestinal Bacterial Overgrowth in Patients Treated With Proton Pump Inhibitors

Sponsor

Mayo Clinic

Enrollment

50 participants

Start Date

Nov 17, 2023

Study Type

INTERVENTIONAL

Conditions

Gastroesophageal Reflux Regurgitation Heartburn

Summary

Researchers hope to determine how often small intestinal bacterial overgrowth occurs after taking proton pump inhibitors.

Eligibility

Min Age: 18 Years

Inclusion Criteria2

Predominant symptoms of gastroesophageal reflux disease including heartburn, regurgitation
Subjects must be able to give appropriate informed consent

Exclusion Criteria9

Prior diagnosis of SIBO
Use of PPIs or H2R-anatagonstists in the prior 3 months
Major concomitant illness (renal, hepatic, rheumatologic or cardiovascular disease, or malignancy)
Antibiotic therapy within one month
Prior gastrointestinal surgery including esophageal, gastric, and small or large bowel surgery
Previously diagnosed irritable bowel syndrome or inflammatory bowel disease
Individuals who are pregnant or breast feeding
Patients with plans to become pregnant
Inability to take PPIs, including allergy/sensitivity

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Interventions

OTHERBreath Testing

Subjects drink a small carbohydrate solution, and then provide a breath sample every 15 minutes for one hour, and then every 30 minutes for the next two hours

Locations(1)

Mayo Clinic Florida

Jacksonville, Florida, United States

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NCT05976165

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