Safety, Tolerability, and Distribution of Laquinimod Eye Drops : The LION Study

The LION Study is a Phase 1 clinical trial testing the safety, tolerability, and distribution of laquinimod — an anti-inflammatory drug — when applied as eye drops in adults scheduled for vitrectomy eye surgery. Researchers want to know how much of the drug reaches different parts of the eye and whether it is safe for topical ophthalmic use, with the long-term goal of treating inflammatory eye conditions. Eligible participants are adults aged 18 or older who are already scheduled for vitrectomy, have stable eye pressure, and are not pregnant, not infected, and do not have significant liver or kidney impairment. Participation involves applying laquinimod eye drops for 2 weeks before surgery, with the drug measured in eye fluid and blood samples collected during the procedure. This summary was prepared to help patients understand the study in plain language.