A First-in-human Study of HyperQureTM", Laparoscopic Renal Denervation Therapy in Patient With Resistant Hypertension

This is a first-in-human trial testing the HyperQure device — a new laparoscopic (keyhole surgery) tool for renal denervation, a procedure that cuts the nerve signals around the kidney arteries to lower blood pressure. This is for people with resistant hypertension — dangerously high blood pressure that does not come down even with 3 or more medications. **You may be eligible if...** - You are 19 to 79 years old - You have high blood pressure that remains elevated (office systolic above 140 mmHg, diastolic above 90 mmHg) despite taking 3 or more different blood pressure medications consistently, including a diuretic - Your blood pressure is confirmed elevated on a 24-hour monitoring test - You are willing to continue your current medications throughout the study **You may NOT be eligible if...** - There are structural problems in your kidney arteries (significant narrowing, stents, or plaques) that make the procedure unsafe - You have had previous renal denervation therapy - You have polycystic kidney disease, a kidney transplant, or a single kidney - You are on dialysis or have very poor kidney function - You have had recent renal artery stenting - You have conditions that make laparoscopic surgery unsafe - You are pregnant Talk to your doctor to see if this trial is right for you.