RecruitingNCT06292104

Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS), Aim 1

Sponsor

University of Texas Southwestern Medical Center

Enrollment

350 participants

Start Date

Mar 5, 2024

Study Type

OBSERVATIONAL

Conditions

This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.

Min Age: 14 Years

POTS Patients
Age ≥ 14 years, able to provide informed consent (assent with parental consent for age < 18) and comply with procedures
Meets consensus criteria for POTS: (1) sustained increase in heart rate ≥ 30 bpm above supine baseline within 10 min of quiet standing or upright tilt (≥ 40 bpm in individuals 12 to 19 years of age) OR sustained upright HR (heart rate) >120 bpm, (2) absence of orthostatic hypotension, (3) symptoms with standing that improve with sitting or lying down, (4) resting supine heart rate < 100 bpm, (5) orthostatic symptoms present for at least 6 months
Stable oral medication regimen for at least 14 days
Non-POTS Control Patients
Healthy women, age 18 - 30 years, able to provide informed consent and comply with study procedures
Does NOT meet consensus criteria for postural tachycardia syndrome
No symptoms of orthostatic intolerance or dysautonomia. No history of other major medical disorder
Resting supine heart rate < 100 bpm

Use of amphetamine-type stimulants, diuretics, selective norepinephrine reuptake inhibitor, anticholinergic medications (including tricyclic antidepressant medications), fludrocortisone, desmopressin in past 14 days
Use of other autonomic drugs (adrenergic agents, pyridostigmine, droxidopa, triptans, ivabradine) in past 48 hours
Currently receiving IVIG (Intravenous immunoglobulin), subcutaneous IgG (Immunoglobulin G), or any investigational medication (in past year)
Infusion of iv fluids in past 7 days
History or evidence of another condition explaining symptoms or orthostatic tachycardia (e.g. structural heart disease, CSF (Cerebrospinal fluid) hypovolemia, or severe traumatic brain injury)

Interested in this trial?

Get notified about updates and connect with the research team.

DIAGNOSTIC_TESTmultimodal diagnostic testing

Serological testing, cardiac MRI, skin biopsy, cardiovascular testing, blood volume measurements

UT Southwestern Medical Center

Dallas, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

NCT06292104