Postural Orthostatic tachycardia Syndrome Clinical Trials

20 recruitingLast updated: May 11, 2026

There are 20 actively recruiting postural orthostatic tachycardia syndrome clinical trials across 7 countries. Studies span Not Applicable, Phase 2. Top locations include Calgary, Alberta, Canada, Nashville, Tennessee, United States, Dallas, Texas, United States. Updated daily from ClinicalTrials.gov.


Postural Orthostatic tachycardia Syndrome Trials at a Glance

20 actively recruiting trials for postural orthostatic tachycardia syndrome are listed on ClinicalTrialsFinder across 6 cities in 7 countries. The largest study group is Not Applicable with 13 trials, with the heaviest enrollment activity in Calgary, Nashville, and Dallas. Lead sponsors running postural orthostatic tachycardia syndrome studies include University of Calgary, Vanderbilt University Medical Center, and Dr. Victoria Claydon.

Browse postural orthostatic tachycardia syndrome trials by phase

Treatments under study

About Postural Orthostatic tachycardia Syndrome Clinical Trials

Looking for clinical trials for Postural Orthostatic tachycardia Syndrome? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Postural Orthostatic tachycardia Syndrome trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Postural Orthostatic tachycardia Syndrome clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 20 trials

Recruiting
Not Applicable

NC Testing in LC & POTS

Postural Orthostatic tachycardia SyndromePost-acute Sequelae of SARS-CoV-2 Infection
University of Calgary100 enrolled1 locationNCT05914649
Recruiting
Not Applicable

Compression Garments in the Community With POTS

Postural Orthostatic tachycardia Syndrome
University of Calgary30 enrolled1 locationNCT04881318
Recruiting
Not Applicable

CAlgary SAlt for POTS

Postural Orthostatic tachycardia Syndrome
University of Calgary50 enrolled1 locationNCT05924646
Recruiting
Not Applicable

Paediatric Syncope in the Emergency Department

Postural Orthostatic tachycardia SyndromeOrthostatic intoleranceSyncope, Vasovagal
Dr. Victoria Claydon300 enrolled1 locationNCT05555771
Recruiting
Not Applicable

Postural Sway and Counterpressure Maneuvers for Pediatric Syncope

Postural Orthostatic tachycardia SyndromeOrthostatic intoleranceSyncope, Vasovagal
Simon Fraser University30 enrolled1 locationNCT05633693
Recruiting
Not Applicable

Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease

Myasthenia GravisAmyotrophic Lateral SclerosisNeuromuscular Diseases (NMD)+15 more
University of Missouri-Columbia50 enrolled1 locationNCT07478172
Recruiting
Not Applicable

Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome

Postural Orthostatic tachycardia SyndromeFunctional Gastrointestinal DisordersAutonomic Nervous System Disease+2 more
Medical College of Wisconsin90 enrolled1 locationNCT05212129
Recruiting
Phase 2

Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS)

Postural Orthostatic Tachycardia Syndrome (POTS)
Regeneron Pharmaceuticals81 enrolled18 locationsNCT06593600
Recruiting

Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research

Traumatic Brain InjuryEhlers-Danlos SyndromePost-Acute COVID-19 Syndrome+41 more
Brain Inflammation Collaborative10,000 enrolled1 locationNCT04806620
Recruiting
Phase 2

Restoring Iron Deficiency in POTS

POTS - Postural Orthostatic Tachycardia Syndrome
Vanderbilt University Medical Center12 enrolled1 locationNCT07197905
Recruiting
Not Applicable

Long COVID Immune Profiling

Autonomic DysfunctionLong COVIDPOTS - Postural Orthostatic Tachycardia Syndrome
Vanderbilt University Medical Center150 enrolled1 locationNCT06027255
Recruiting

Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Nat hx With Its Numerous Co-morbidities?

POTS - Postural Orthostatic Tachycardia Syndrome
Virginia Commonwealth University120 enrolled1 locationNCT06616363
Recruiting

POLish Registry of CArdioneuroablation and CArdioneuromodulation

Autonomic DysfunctionPostural Orthostatic Tachycardia Syndrome (POTS)Ventricular Arrythmia+9 more
SABAMED Medical Center Ltd.1,000 enrolled1 locationNCT07196397
Recruiting
Not Applicable

Programming Aquatic Therapy for POTS

Postural Orthostatic Tachycardia Syndrome (POTS)
California State University, Dominguez Hills12 enrolled1 locationNCT07182578
Recruiting

Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

Postural Orthostatic tachycardia Syndrome
University of Texas Southwestern Medical Center350 enrolled1 locationNCT06292104
Recruiting
Not Applicable

POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS

HealthyPostural Orthostatic Tachycardia Syndrome (POTS)
University of Copenhagen30 enrolled1 locationNCT07019519
Recruiting
Not Applicable

The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome

POTS - Postural Orthostatic Tachycardia Syndrome
Lund University200 enrolled1 locationNCT05554107
Recruiting
Not Applicable

The Long COVID-19 Wearable Device Study

Postural Orthostatic tachycardia SyndromeMyalgic EncephalomyelitisChronic Fatigue Syndrome+3 more
Scripps Translational Science Institute100,500 enrolled1 locationNCT05741112
Recruiting
Not Applicable

Counterpressure Maneuvers in Postural Orthostatic Tachycardia Syndrome

Postural Orthostatic Tachycardia Syndrome (POTS)
Medical University Innsbruck40 enrolled1 locationNCT06936319
Recruiting

The Australian Postural Orthostatic Tachycardia Syndrome Patient Registry

Postural Orthostatic tachycardia Syndrome
The University of Adelaide1,000 enrolled1 locationACTRN12621001034820