RecruitingNCT06325618

Lymphedema, Low-grade Inflammation and the Vasculature in Turner Syndrome


Sponsor

University of Aarhus

Enrollment

150 participants

Start Date

Jan 8, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

100 women with karyotype verified TS, previously examined at 4 study visits during a 19-year period will be asked to participate in a 5th study visit. Healthy age-matched females will be included as controls in a ratio 2:1. The aim is to examine and quantify the cardiovascular and lymphatic system in women with TS. The investigators will study a possible causal mechanism between the known pathologic phenotype and alterations in these systems to understand, prevent or treat the life-threatening complications in TS.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 100 Years

Inclusion Criteria1

  • Turner Syndrome

Exclusion Criteria2

  • pregnancy
  • contraindications for MRI

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Interventions

OTHERNo intervention other than obtaining biopsies

Skin, fat, and muscle biopsies will be obtained

DRUGIndocyanine green (ICG)

Indocyanine green will be injected to evaluate the lymphatic system.


Locations(1)

Aarhus University Hospital

Aarhus N, Denmark

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NCT06325618


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