Xeltis Hemodialysis Access (aXess) Conduit: aXess-E Study

This study tests a new type of hemodialysis access conduit called aXess-E, made from a specially engineered bioabsorbable material. People with kidney failure who need hemodialysis require a reliable access point in the arm (called an arteriovenous graft or AVG) to connect to the dialysis machine. The aXess-E conduit is designed to last longer and work better than standard synthetic grafts by promoting natural tissue growth around it. **You may be eligible if...** - You have end-stage kidney disease and need hemodialysis - You need a new arteriovenous graft placed in your upper arm - You are 18 or older - You have suitable vein anatomy (target vein at least 5 mm in diameter) - You have a life expectancy of at least 12 months **You may NOT be eligible if...** - You have severe heart failure (NYHA Class IV or ejection fraction below 25%) - You have had a recent heart attack or major cardiovascular event - You have active infections or bleeding problems - You are pregnant - You have had prior failed grafts in the target arm Talk to your doctor to see if this trial is right for you.