RecruitingNCT06335836

The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)

Sponsor

The First Affiliated Hospital with Nanjing Medical University

Enrollment

209 participants

Start Date

Mar 1, 2024

Study Type

OBSERVATIONAL

Conditions

Alzheimer Disease Mild Cognitive Impairment Subjective Cognitive Decline SCD MCI AD Social Isolation

Summary

The goal of this clinical trial is to learn about the effects of social isolation and social interaction on the risk of dementia progression and brain function in SCD 1. To explore the association between social isolation and lonely SCD populations and the occurrence and progression of MCI and AD through cross-sectional studies, cohort studies and randomized controlled trials of SCD; 2. To clarify the correlation between different carrier states, resting brain function connectivity characteristics, and dual-task walking ability of APOEε4 allele and the progression of SCD to MCI and AD during the cognitive progress of people with SCD affected by social isolation; 3. Establish a predictive model of cognitive decline from SCD to MCI and AD, and apply it to the SCD population to carry out individualized interventions; 4. Confirm the protective effect of social interaction on cognitive level and brain function in SCD patients.

Eligibility

Min Age: 45 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is examining whether social isolation or social interaction influences the risk of developing Alzheimer's disease or other forms of dementia in older adults who currently have subjective cognitive decline — meaning they feel their memory is slipping, but standard tests are still normal. **You may be eligible if...** - You are between 45 and 85 years old - You feel that your thinking or memory has declined compared to your previous normal, but this is not explained by a recent event or illness - Standard cognitive tests show your performance is still within the normal range - You are able to sign the informed consent form yourself **You may NOT be eligible if...** - You are under 45 or over 85 years old - You have been diagnosed with dementia or a major neurological condition - You have significant hearing, vision, or language impairments that prevent neuropsychological testing - You have had substance abuse issues in the past 6 months - You have severe diabetes or other significant health conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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