RecruitingNot ApplicableNCT06366399

The Acute T-Rex (Timing of Resistance Exercise) Study

Timing (AM v PM) of Acute Resistance Exercise on Glycemic Control in Older Adults: The Acute T-Rex Study

Sponsor

University of Utah

Enrollment

20 participants

Start Date

Nov 15, 2023

Study Type

INTERVENTIONAL

Conditions

Insulin Resistance Diabetes Mellitus, Type 2 Sleep Disturbance Insulin Sensitivity Glucose Intolerance Overweight or Obesity

Summary

The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.

Eligibility

Min Age: 50 YearsMax Age: 74 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether the time of day that older adults do resistance (strength) exercise affects how their bodies process food and manage blood sugar, particularly in people who are overweight. **You may be eligible if...** - You are a man or woman between 50 and 74 years old of any ethnicity - You have a BMI of 25 or higher (overweight or obese) - Your weight has been stable over the past 6 months - You are generally healthy and not currently meeting exercise guidelines **You may NOT be eligible if...** - You have uncontrolled heart, metabolic, kidney, or lung disease - You have been treated for cancer in the past 5 years - You have a physical limitation preventing resistance exercise - You are taking certain medications that affect blood sugar or metabolism Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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