RecruitingNCT06430554

Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability

Personalized Ventilatory Strategy Based on Ventilation-perfusion Mismatch and Lung Recruitability in Moderate-to-severe ARDS Patients

Sponsor

Zhongda Hospital

Enrollment

40 participants

Start Date

Jun 8, 2024

Study Type

OBSERVATIONAL

Conditions

Mechanical Ventilation Respiratory distress syndrome Positive-Pressure Respiration

Summary

This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung recruitability.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Inclusion Criteria5

age ≥18 years
Moderate-to-severe ARDS as per the 2023 ESICM definition
Undergoing invasive mechanical ventilation
Planned prone position based on the attending physicians' decisions
Signed informed consent

Exclusion Criteria8

age ≥85 years
Pregnancy
Severe hemodynamic instability (> 30% increase in vasopressors in the last 6 hours or norepinephrine > 0.5 µg/kg/min)
Clinically suspected elevated intracranial pressure (>18 mm Hg)
Bronchopleural fistula
Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement)
Severe hypernatremia (>170mmol/L)
Re-admission of patients already enrolled in this study, or patients who are participating in other studies