RecruitingNot ApplicableNCT06473844

Efficacy of SGLT2 Inhibitors in Adults With Sepsis

Efficacy and Safety of Sodium-Glucose Cotransporter 2 Inhibitors in Adults With Sepsis: A Feasibility Study for a Multicenter Double-Blind Randomized Placebo-Controlled Trial


Sponsor

Hospital Authority, Hong Kong

Enrollment

60 participants

Start Date

Mar 5, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Goal of this clinical trial is to examine the safety and efficacy of SGLT2 inhibitors on the clinical outcomes in patients with sepsis. Main study outcomes are as follows: (i) Primary objective is to examine the efficacy and safety of SGLT2 inhibitors on clinical outcomes in patients with sepsis. (ii) Secondary objective is to examine the effect of SGLT2 inhibitors on inflammatory markers in patients with sepsis.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Empagliflozin 10 MG and a drug called Placebo for people with critically ill, inflammation, and other related conditions. The study is currently recruiting participants at 3 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGEmpagliflozin 10 MG

Empagliflozin 10mg once daily from recruitment to hospital discharge

DRUGPlacebo

Placebo single tablet once daily from recruitment to hospital discharge


Locations(3)

4/F Main Clinical Block and Trauma Centre, Prince of Wales Hospital, Shatin, New Territories, Hong Kong

Hong Kong, Hong Kong, Hong Kong

Adult Intensive Care Unit, Queen Mary Hospital, 102 Pok Fu Lam Road, Hong Kong

Hong Kong, Hong Kong, Hong Kong

The University of Hong Kong

Hong Kong, Hong Kong

View Full Details on ClinicalTrials.gov

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NCT06473844


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