Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG
Xuanwu Hospital, Beijing
20 participants
Jul 8, 2024
INTERVENTIONAL
Conditions
Summary
This study aims to collect electrophysiological and clinical data from patients aged 14-65 with drug-resistant epilepsy who underwent SEEG. The collected data will be analyzed to investigate the functional connectivity during wakefulness and sleep states.
Eligibility
Inclusion Criteria4
- Drug-resistant focal epilepsy
- Justified SEEG exploration in the context of presurgical assessment of epilepsy
- Subjects will be a part of the epilepsy-monitoring unit for long-term SEEG recordings and analysis
- Written non-opposition to study participation
Exclusion Criteria2
- Pregnant women (Contraindication to SEEG exploration)
- Subjects that experience surgical complications during the implant procedure will be excluded from the study
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Interventions
This study will utilize stereoelectroencephalography (SEEG) recordings combined with single-pulse electrical stimulation (SPES) to investigate functional brain connectivity and cortical excitability patterns in patients with epilepsy during both wakefulness and sleep states. The SEEG recordings will provide high-resolution intracranial electrophysiological data, while SPES will be employed to actively probe and quantify cortico-cortical connections. This combined approach will enable characterization of state-dependent neural network dynamics.
Locations(1)
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NCT06524479