RecruitingNCT06539702

Preoperative Hemogram Parameters and BRAF Molecular Test Detected by Bethesda 3 Cytology.

To Reveal the Predictive Value of Preoperative Hemogram Parameters and BRAF Molecular Test in Predicting Malignancy in Cases With Thyroid Nodules Detected by Bethesda 3 Cytology.


Sponsor

Saglik Bilimleri Universitesi

Enrollment

120 participants

Start Date

Jul 20, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The main hypothesis of this study is that preoperative hemogram parameters can be used as biomarkers for malignancy in patients with thyroid nodule Bethesda 3 cytology. The secondary hypothesis is that BRAF molecular testing has a high predictive value in predicting malignancy in patients with thyroid nodule Bethesda 3 cytology. Primary outcome: Preoperative hemogram parameters. Secondary outcome: BRAF positivity.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This observational study is examining whether routine blood test results (like white blood cell counts, known as a hemogram) and a genetic mutation test (BRAF) can help predict which thyroid nodules with uncertain results on needle biopsy (called Bethesda III or "indeterminate" results) are actually cancerous. The goal is to improve decision-making around thyroid surgery. **You may be eligible if...** - You are between 18 and 75 years old - Your thyroid nodule biopsy came back as "indeterminate" (Bethesda III classification) - You have been scheduled for thyroid removal surgery (thyroidectomy) **You may NOT be eligible if...** - You have cancer in another part of your thyroid besides the nodule being studied - Your preoperative blood test (hemogram) results are not available - You decline to participate in the BRAF genetic testing Talk to your doctor to see if this trial is right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Prof. Dr. Cemil Tascioglu City Hospital

Istanbul, Turkey (Türkiye)

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NCT06539702


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