RecruitingPhase 1NCT06574568

A Study of YKST02 in Participants With Relapsed or Refractory Multiple Myeloma

A Multicenter, Open-label, Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Efficacy of YKST02 in Participants With Relapsed or Refractory Multiple Myeloma


Sponsor

Excyte Biopharma Ltd

Enrollment

70 participants

Start Date

Jun 14, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to provide a basis for further clinical development of YKST02. YKST02 is a study medicine that targets multiple myeloma and activates the human body to fight against this disease.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study tests a new drug called YKST02 in people with multiple myeloma (a blood cancer) that has relapsed (come back) or become refractory (stopped responding to treatment). It is an early-phase study looking at safety and the right dose. **You may be eligible if...** - You have been diagnosed with multiple myeloma per standard criteria - You have received at least two prior classes of treatment, including an immunomodulatory drug (e.g., lenalidomide), a proteasome inhibitor (e.g., bortezomib), and an anti-CD38 drug (e.g., daratumumab) - You have measurable disease in your blood, urine, or free light chains - Your performance status and organ function are adequate **You may NOT be eligible if...** - You have not had enough prior lines of therapy - You have serious organ problems or active infections - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGYKST02

BCMA-CD3 bispecific antibody


Locations(12)

Beijing Chao-yang Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Beijing Jishuitan Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Shunde Hospital of Southern Medical University

Foshan, Guangdong, China

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China

Sun Yat-sen Memorial Hospital

Guangzhou, Guangdong, China

Guangxi Medical University Cancer Hospital

Nanning, Guangxi, China

Harbin Medical University Cancer Hospital

Harbin, Heilongjiang, China

Henan Cancer Hospital

Zhengzhou, Henan, China

Affiliated Zhongshan Hospital of Dalian University

Dalian, Liaoning, China

Shandong Cancer Hospital

Jinan, Shandong, China

Shanxi Cancer hospital

Taiyuan, Shanxi, China

The First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06574568


Related Trials