RecruitingNCT06584604

Calibration of Esophageal Balloon Catheter in Spontaneous and Mandatory Mechanical Ventilation

Calibration of Esophageal Balloon Catheter in Spontaneous and Mandatory Mechanical Ventilation (PESCA)


Sponsor

Leiden University Medical Center

Enrollment

40 participants

Start Date

Dec 29, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Calibration of the esophageal balloon catheter (Pes catheter) is important for the right measurement of the esophageal pressure (Pes) and subsequent interpretation of the derived transpulmonary pressures during mechanical ventilation. Both relative changes and absolute values of Pes can be affected by inappropriate filling of the esophageal balloon and by the elastance of the esophagus wall. Therefore one should calibrate the balloon to determine the best filling pressure. Calibration of the Pes catheter has only been validated in mandatory ventilation but not in support modes in which the patient triggers the ventilator and is supported by the mechanical ventilator. Because the forces in the thoracic cage behave differently in comparison with a controlled mode, it is to be expected that the calibration process in a support mode yields different filling volumes in comparison with the calibration process in a controlled mode. This would lead to a more reliable filling volume in support mechanical ventilation and a more reliable derivation of transpulmonary pressure and therefore to a better treatment of patients.


Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • years or older.
  • Mechanically ventilated in spontaneous mode.
  • Sedated (Richmond Agitation Sedation Scale (RASS) between -3 and -5).
  • Pes catheter in situ according to the protocol used in the LUMC (Insertion of a Pes catheter is mandatory if it is suspected that te patient will be ventilated for more than 24 hrs.).

Exclusion Criteria4

  • Medical condition that excludes the placement of a Pes catheter.
  • Allergic reaction against rocuronium in the past.
  • Pregnant.
  • RASS \> -3

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Interventions

OTHERThere is no intervention

There is no intervention


Locations(1)

Leiden University Medical Center

Leiden, South Holland, Netherlands

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NCT06584604


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