Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux

This study tests a non-endoscopic device called EsoCheck (a small pill-sized capsule that collects esophageal cells without a full scope procedure) to screen for Barrett's esophagus — a condition where stomach acid damages the esophagus lining and can lead to esophageal cancer — in veterans who don't have classic heartburn symptoms but have other risk factors. **You may be eligible if...** - You are between 40 and 85 years old - You have never had an upper endoscopy (scope of the esophagus/stomach) - You do NOT have chronic heartburn or reflux - You have at least 3 risk factors for Barrett's esophagus, such as: being male, white race, obesity (BMI > 30), smoking history, or a family history of Barrett's or esophageal cancer - You have no significant swallowing problems or blood-clotting issues **You may NOT be eligible if...** - You have had an upper endoscopy in the past 10 years - You have weekly heartburn or reflux symptoms lasting 5+ years - You are on blood thinners that cannot be safely stopped - You have known esophageal varices, stricture, or a history of esophageal/gastric surgery - You have had a heart attack or stroke in the past 6 months Talk to your doctor to see if this trial is right for you.