Non-Endoscopic Detection of Barrett's Esophagus Using Methylation Biomarkers on EndoSign® Cell Collection Device Samples

This study is testing a non-invasive swallowable device to detect Barrett's esophagus — a condition where the lining of the food pipe changes, which can sometimes lead to cancer — without needing a traditional camera scope procedure. **You may be eligible if...** - You have already been diagnosed with Barrett's esophagus (at least 1 cm long), including cases with or without early cell changes - You are scheduled for a standard endoscopy procedure - You are willing to swallow the study device before your endoscopy **You may NOT be eligible if...** - Your previous endoscopy result was unclear about whether abnormal cells were present - You have already had endoscopic treatment to remove Barrett's tissue - You have trouble swallowing (unable to swallow a small capsule about the size of a large pill) - You have or may have varicose veins in your esophagus or stomach - You take blood-thinning medications that cannot be stopped - You take GLP-1 medications (like Ozempic) that cannot be paused for 1 week - You have had prior surgery on your stomach or esophagus - You had a heart attack or stroke in the past 6 months - You are pregnant Talk to your doctor to see if this trial is right for you.