Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery
A Randomized Double-Blind Trial Comparing Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery
Ain Shams University
75 participants
Feb 20, 2025
INTERVENTIONAL
Conditions
Summary
This study aims to compare lidocaine and dexmedetomidine infusion and their combination on perioperative pain in patients undergoing video-assisted thoracoscopic surgery.
Eligibility
Inclusion Criteria4
- Age ≥18 years old.
- Both sexes.
- American Society of Anesthesiologists (ASA) physical status of I, II.
- Patients undergoing video-assisted thoracoscopic surgery (VATS) under general anesthesia.
Exclusion Criteria9
- Hypersensitivity to any of the used drugs.
- Coagulation disorder.
- Body mass index \>35 kg/m2.
- History of chronic pain requiring daily opioids/steroids/clonidine/other α2 agonist/analgesics or any drugs acting on the central nervous system during the previous 2 weeks, and drug/alcohol abuse.
- Contraindication to the use of local anesthetics.
- Cardiovascular disease.
- Severe respiratory, renal or hepatic impairment.
- Insulin-dependent diabetes mellitus.
- Central nervous system or psychiatric disease.
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Interventions
Patients will receive lidocaine 0.3 mg/kg over 10 min loading, 0.3 mg/kg/h infusion after induction of anesthesia as maintenance dose till 10 min before the end of the operation plus saline 0.9% with same rate of dexmedetomidine.
Patients will receive dexmedetomidine 0.5 μg/kg infusion over 10 min as a loading dose then 0.5 μg/kg/h after induction of anesthesia as maintenance dose till 10 min before the end of the operation plus saline 0.9% with same rate of lidocaine.
Patients will receive lidocaine (0.3 mg/kg in 10 min loading, 0.3 mg/kg/h infusion) and dexmedetomidine infusions (0.5 μg/kg infusion over 10 min as a loading dose then 0.5 μg/kg/h) till 10 min before the end of the operation.
Locations(1)
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NCT06837519