Post-stroke Depression Clinical Trials

8 recruitingLast updated: June 18, 2026

There are 8 actively recruiting post-stroke depression clinical trials across 6 countries. Studies span Not Applicable, Phase 2. Top locations include Charleston, South Carolina, United States, Chongqing, China, Durham, North Carolina, United States. Updated daily from ClinicalTrials.gov.


Post-stroke Depression Trials at a Glance

8 actively recruiting trials for post-stroke depression are listed on ClinicalTrialsFinder across 6 cities in 6 countries. The largest study group is Not Applicable with 6 trials, with the heaviest enrollment activity in Charleston, Chongqing, and Durham. Lead sponsors running post-stroke depression studies include Duke University, Medical University of South Carolina, and Assaf-Harofeh Medical Center.

Browse post-stroke depression trials by phase

Treatments under study

About Post-stroke Depression Clinical Trials

Looking for clinical trials for Post-stroke Depression? There are currently 8 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Post-stroke Depression trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Post-stroke Depression clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 18 of 8 trials

Recruiting
Not Applicable

Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors

Post-stroke DepressionSubthreshold Depression
The University of Texas Health Science Center, Houston350 enrolled1 locationNCT06864715
Recruiting
Not Applicable

Hyperbaric Oxygen Therapy for Persistent Post Stroke Depression

Post-stroke Depression
Assaf-Harofeh Medical Center142 enrolled1 locationNCT07423273
Recruiting

Construction and Clinical Validation Study of a Prediction Model for Depression After Ischemic Stroke

Post-stroke Depression
Min Su488 enrolled1 locationNCT07294274
Recruiting
Phase 2

Allopregnanolone (Zuranolone) in Post-stroke Depression

Post-stroke Depression
Duke University6 enrolled1 locationNCT06759558
Recruiting
Not Applicable

Physical Capacity Building for Chronic Stroke

StrokePost-stroke Depression
Medical University of South Carolina76 enrolled1 locationNCT07039305
Recruiting
Not Applicable

The Effects of Naturalistic Light on Post Stroke Complications Related Brain Areas in Stroke Patients During Admission for Rehabilitation.

StrokePost-stroke DepressionPost-stroke Fatigue+1 more
Rigshospitalet, Denmark45 enrolled1 locationNCT06922409
Recruiting
Not Applicable

Transcranial Direct Current Stimulation on Post Stroke Depression

Post-stroke Depression
Riphah International University56 enrolled1 locationNCT06598670
Recruiting
Not Applicable

Efficacy and Safety of Auricular Acupuncture in Treating Insomnia Post-stroke

Post-stroke DepressionInsomnia, Secondary
University of Medicine and Pharmacy at Ho Chi Minh City60 enrolled1 locationNCT06540664