Hyperbaric Oxygen Therapy for Persistent Post Stroke Depression

This study is testing hyperbaric oxygen therapy — breathing pure oxygen in a pressurized chamber — as a treatment for depression that develops after a stroke. Researchers want to see if this approach can help people whose post-stroke depression has not improved enough with antidepressant medications. **You may be eligible if...** - You are between 50 and 85 years old - You had an ischemic (clot-related) stroke between 6 months and 7 years ago - You have been diagnosed with depression after your stroke, with a significant score on a depression rating scale - You have been on antidepressant medication for at least 3 months - Your mental health treatment has been stable for more than 3 months **You may NOT be eligible if...** - You had depression, schizophrenia, or bipolar disorder before your stroke - You have significant communication problems (aphasia) or major cognitive decline - You have had deep brain stimulation surgery or a traumatic brain injury - You are unable to attend clinic visits Talk to your doctor to see if this trial is right for you.