RecruitingNCT06912321

Characteristics of Papez Loop Neural Network in T2DM （Type 2 Diabetes Mellitus）

Construction of Papez Loop Neural Network Feature Recognition Model and Prediction Model of Cognitive Impairment Progression Related to Insulin Resistance in Type 2 Diabetes Mellitus

Sponsor

Nanjing First Hospital, Nanjing Medical University

Enrollment

400 participants

Start Date

May 1, 2024

Study Type

OBSERVATIONAL

Conditions

Insulin Resistance Cognitive Impairment Type 2 Diabetes

Summary

This is a cross-sectional and longitudinal study to investigate the characteristic changes in Papez's circuit neural network activity and connectivity based on multimodal MRI, and through follow-up study of the interaction between the internal brain regions of Papez circuit and the function of the external neural network, a prediction model of the characteristic changes of Papez circuit neural network was constructed based on machine learning technology.

Eligibility

Min Age: 45 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is using brain MRI scans to examine how type 2 diabetes affects the brain's memory and emotion circuits — specifically a network called the Papez loop — in middle-aged adults. **You may be eligible if...** - You are between 45 and 70 years old - You are right-handed - You have at least 8 years of education - You have been diagnosed with type 2 diabetes for 3–20 years — OR — you have normal blood sugar levels (for the healthy comparison group) - You have no MRI contraindications (such as metal implants) **You may NOT be eligible if...** - You have had a severe low blood sugar event or acute diabetes complications - You have a history of stroke, Alzheimer's disease, epilepsy, Parkinson's disease, or other neurological conditions - You have a history of depression, mania, or alcohol dependence - You have had a recent surgery or infection in the past month Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.