Spatial Memory Training and Cognitive Function

Exclusion Criteria19

• Self-reported having either of the following:
• Current post-traumatic stress disorder and/or generalized anxiety disorder; Substance use disorder; Significant heart disease (i.e., stroke occurring during 5 years prior to study assessment or cardiac disease non-stabilized with medication); Severe Depression, or a Geriatric Depression Scale (GDS) score greater than 12; Current insomnia disorder.
• Current medications for sleep problems, or use of medications that affect sleep.
• Use of antidepressant and anti-anxiety medication for less than 3 months prior to study entry.
• Use of analgesics with codeine (or other opioids).
• Use of antipsychotic medication (past or current).
• Having undergone brain surgery or ECT.
• Self-reported colour-blindness.
• General anesthesia in the past year.
• Current smoker.
• Suspected or confirmed traumatic brain injury during the last 24 months.
• Motion sickness or intolerant to virtual reality tasks.
• Cholesterol or hypertension medication for less than 3 months or changes expected within the next 9 months.
• History or presence of neurological or psychiatric disorders (other than MCI) that in the opinion of the investigator may compromise patient safety or study objectives.
• Current severe medical conditions (e.g. untreated diabetes, cancer) that in the opinion of the investigator may compromise patient safety or study objectives.
• For female participants, severe menopausal symptoms, including hot flashes (determined from the Greene climacteric scale - any participants scoring over 15 is excluded).
• Use of computer games that are designed to help with memory or general cognition.
• Presence of any medical or psychological condition that, in the opinion of the principal investigator, may compromise the study objectives.
• Presence of contra-indications for MRI scanning.