RecruitingNot ApplicableNCT07139093

Testing of an Interface for Synchronizing tACS-DBS With a Phase-locked-loop


Sponsor

Universitätsklinikum Hamburg-Eppendorf

Enrollment

2 participants

Start Date

Aug 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The investigators aim to test an interface to phase-lock transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS) for future studies investigating the effects of different time-lags between DBS and tACS on the behavioural and neural level. To test if the interface works in patients with DBS, the investigators record EEG during synchronized tACS-DBS in several patients. The investigators hypothesize that they can apply tACS at the desired phase-lags relative to DBS pulses and confirm this with EEG measurements of the DBS and tACS artifact.


Eligibility

Min Age: 35 YearsMax Age: 85 Years

Inclusion Criteria4

  • Provision of written informed consent by the patient
  • Age 35 - 85
  • patient groups: Parkinson's disease, essential tremor, dystonia
  • \>3 months after surgery for DBS

Exclusion Criteria3

  • Epilepsy or history of seizures
  • Existence of heart pacemaker or other metal implants in the body (except DBS)
  • Pregnancy

Interventions

DEVICEDBS-coupled tACS

tACS will be applied in a phase-coupled manner, so that tACS and DBS are synchronized


Locations(1)

University Medical Center Hamburg-Eppendorf

Hamburg, Germany

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NCT07139093


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