RecruitingNot ApplicableNCT07139093

Testing of an Interface for Synchronizing tACS-DBS With a Phase-locked-loop


Sponsor

Universitätsklinikum Hamburg-Eppendorf

Enrollment

2 participants

Start Date

Sep 30, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The investigators aim to test an interface to phase-lock transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS) for future studies investigating the effects of different time-lags between DBS and tACS on the behavioural and neural level. To test if the interface works in patients with DBS, the investigators record EEG during synchronized tACS-DBS in several patients. The investigators hypothesize that they can apply tACS at the desired phase-lags relative to DBS pulses and confirm this with EEG measurements of the DBS and tACS artifact.


Eligibility

Min Age: 35 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a brain stimulation technique called transcranial alternating current stimulation (tACS) can be synchronized with a deep brain stimulator (DBS) device in people who already have a DBS implant for Parkinson's disease. The goal is to assess the safety and feasibility of combining these two brain stimulation approaches. **You may be eligible if...** - You already have a deep brain stimulator (DBS) implanted for Parkinson's disease or another approved condition - Your DBS device is compatible with the study's synchronization interface - You are in stable health and able to attend study sessions **You may NOT be eligible if...** - You have a DBS device that is incompatible with external stimulation - You have a history of seizures - You have metal implants in your head besides the DBS that could interact with tACS - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEDBS-coupled tACS

tACS will be applied in a phase-coupled manner, so that tACS and DBS are synchronized


Locations(1)

University Medical Center Hamburg-Eppendorf

Hamburg, Germany

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NCT07139093


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