RecruitingNCT07197255

Transcriptomic Profiling of Cumulus Cells From CAPA-IVM

Transcriptomic Profiling of Cumulus Cells From CAPA-IVM Cycles in Women With PCOS: A Prospective Pilot Study

Sponsor

Mỹ Đức Hospital

Enrollment

10 participants

Start Date

Oct 16, 2025

Study Type

OBSERVATIONAL

Conditions

PCOS (Polycystic Ovary Syndrome)Cumulus Cell Capacitation IVM Transcriptomic Profiling

Summary

Capacitation in vitro maturation (CAPA-IVM) has improved oocyte maturation and resulted in live births. Because cumulus cells (CCs) communicate bidirectionally with the oocyte, their transcriptomic profile may serve as a non-invasive biomarker of oocyte and embryo competence. This prospective pilot study will analyze CCs gene expression after CAPA-IVM using RNA sequencing and pathway analysis, and correlate findings with embryological outcomes including fertilization, day-3 cleavage, and blastocyst formation. Results are expected to provide insights into the molecular basis of oocyte competence and support development of non-invasive embryo selection strategies.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 38 Years

Plain Language Summary

Simplified for easier understanding

This study is examining the biology of egg cells in women with polycystic ovary syndrome (PCOS) who are undergoing a special fertility treatment called CAPA-IVM (an in-vitro maturation method that avoids hormone injections). Researchers want to understand the cells surrounding the egg to improve fertility treatments. **You may be eligible if...** - You are a woman aged 18–38 - You have been diagnosed with PCOS - Your BMI is 32 or below - You have high levels of a hormone called AMH (a sign of many egg-containing follicles) - You have 24 or more small follicles in your ovaries on ultrasound - You are scheduled to undergo CAPA-IVM fertility treatment **You may NOT be eligible if...** - Your partner's sperm was collected through surgery - You have had a previous IVF cycle that produced only immature eggs Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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