"Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy"

This Phase 4 clinical trial examines whether taking ibuprofen (400 mg, three times a day for 3 days) around the time of a full-mouth deep cleaning procedure (root surface debridement) can reduce the acute inflammatory response — measured by blood markers including hs-CRP, procalcitonin, and interleukin-6 — that commonly follows this dental treatment for periodontitis (gum disease). The study compares adults who receive ibuprofen before and after the procedure to those who undergo the procedure without ibuprofen. Systemically healthy adults over 18 with generalized unstable periodontitis and pocket depths of at least 4 mm, who have no allergy to NSAIDs, no peptic ulcer disease, and no recent periodontal treatment in the last 3 months, may be eligible. Participation involves a baseline dental assessment, the cleaning procedure, and a follow-up visit at 1 week with blood tests and questionnaires. This summary was generated by AI to help patients understand the study in plain language.