RecruitingPhase 4NCT07459049

"Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy"

Efficacy Of Ibuprofen In Reducing Acute Inflammatory Response Following One Stage Non- Surgical Periodontal Therapy (A Randomized Clinical Trial )

Sponsor

University of Baghdad

Enrollment

30 participants

Start Date

Dec 1, 2025

Study Type

INTERVENTIONAL

Conditions

Periodontitis

Summary

The goal of this ( Clinical Trial ) is to evaluate the efficacy of Ibuprofen in reducing acute inflammatory response (hs-CRP, ProCT, IL-6) after one hour and one week following one stage non surgical periodontal therapy. The main question it aims to answer is: "Does Ibuprofen effectively reduce the acute inflammatory response ( hs-CRP, ProCT, IL-6) following one-stage non-surgical periodontal therapy?"

Eligibility

Min Age: 18 Years

Inclusion Criteria6

systemically healthy patients.
having a minimum of 20 teeth.
Generalized unstable periodontitis.
Pocket depth \[≥ 4 mm\].
All included participants should be adults aged more than 18 years .
smokers and non smokers

Exclusion Criteria12

Allergy or hypersensitivity to Ibuprofen or other NSAIDs.
current systemic anti-inflammatory or antibiotic therapy (\<3 months).
peptic ulcer disease.
recent periodontal therapy (\<3 months).
Asthma.
Renal impairment .
Hepatic impairment.
Severe cardiac disease (heart failure, hypertension (.
Bleeding disorders (e.g., hemophilia) or patients taking anticoagulants .
Any participant who had known or suspected high risk for tuberculosis, hepatitis B or HIV infections.
pregnant or lactating females.
those being unable to provide written informed consent.

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Interventions

PROCEDURENon surgical root surface debridement in one stage without receiving Ibuprofen

Control group: After one week from baseline visit which include supragingival debridement by using ultrasonic device . sites will receive root surface debridement (RSD) using area specific (Gracey) curettes (Medesy, Italy). Without receiving Ibuprofen.

DRUGNon surgical root surface debridement in one stage with receiving Ibuprofen

Test group: After one week from baseline visit which include supragingival debridement by using ultrasonic device . Test group will receive first dose of Ibuprofen (400 mg) administer one hour before root surface debridement and the subsequent doses will be taken 3 times daily for a duration of 3 days after RSD.