Esketamine Clinical Trials

16 recruiting

Esketamine Trials at a Glance

18 actively recruiting trials for esketamine are listed on ClinicalTrialsFinder across 6 cities in 2 countries. The largest study group is Phase 4 with 9 trials, with the heaviest enrollment activity in Beijing, Beijing, and Nanjing. Lead sponsors running esketamine studies include Peking University First Hospital, Beijing Tiantan Hospital, and Nanjing First Hospital, Nanjing Medical University.

Browse esketamine trials by phase

Treatments under study

About Esketamine Clinical Trials

Looking for clinical trials for Esketamine? There are currently 16 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Esketamine trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Esketamine clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 118 of 18 trials

Recruiting
Phase 4

Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery

SurgeryEsketamineDexmedetomidine+1 more
Peking University First Hospital316 enrolled1 locationNCT07308756
Recruiting
Not Applicable

The Efficacy and Safety of Short Term S-ketamine Infusion as an Adjunctive Therapy in Patients With Fibromyalgia

EsketamineFibromyalgiaPregabalin
Beijing Tiantan Hospital106 enrolled1 locationNCT07230171
Recruiting
Early Phase 1

Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study

DepressionEsketamineAdolescent+1 more
Min Su220 enrolled2 locationsNCT07247968
Recruiting
Phase 4

Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia

EsketamineDexmedetomidinePreoperative Anxiety+5 more
Second Affiliated Hospital of Wenzhou Medical University80 enrolled2 locationsNCT06853431
Recruiting
Phase 4

Sedation With Dexmedetomidine-esketamine Combination and Delirium in ICU Patients

Older PatientsEsketamineDexmedetomidine+3 more
Peking University First Hospital100 enrolled1 locationNCT07151716
Recruiting
Phase 4

Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery

EsketamineDexmedetomidineScoliosis Correction
Peking University First Hospital312 enrolled1 locationNCT06062550
Recruiting
Phase 4

Effect of Dexmedetomidine and Esketamine on Catheter-related Bladder Discomfort

EsketamineDexmedetomidineUrinary Catheter+1 more
Peking University First Hospital1,740 enrolled2 locationsNCT06399185
Recruiting
Phase 4

Immunoinflammatory Regulation of Esketamine in Septic Patients

SepsisInflammatory ResponseEsketamine+1 more
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology100 enrolled2 locationsNCT04843982
Recruiting
Not Applicable

Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation

EsketamineDexmedetomidineRemimazolam
Maternal and Child Health Hospital of Hubei Province150 enrolled1 locationNCT07050212
Recruiting
Phase 4

Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery

EsketamineDexmedetomidineAdults+2 more
Peking University First Hospital476 enrolled1 locationNCT06859892
Recruiting
Not Applicable

Effect of Subanesthetic Dose of Esketamine on Sleep Quality

Breast Cancer SurgeryInsomniaEsketamine
Nanjing First Hospital, Nanjing Medical University184 enrolled1 locationNCT06773143
Recruiting
Phase 4

Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery

DexmedetomidineSleep Wake DisordersEsketamine and the Quality of Recovery
Nanjing First Hospital, Nanjing Medical University180 enrolled2 locationsNCT06778811
Recruiting
Phase 3

Fentanyl or Esketamine for Traumatic PAIN (FORE-PAIN) Trial

AnalgesiaEsketamineFentanyl+2 more
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)608 enrolled1 locationNCT06051227
Recruiting
Not Applicable

Esketamine on Postoperative Sleep Disturbance of Patients Undergoing Spinal Surgery

Sleep DisturbanceEsketamine
Beijing Tiantan Hospital156 enrolled1 locationNCT06451627
Recruiting
Phase 4

Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA

SurgeryEsketamineDexmedetomidine+2 more
Peking University First Hospital100 enrolled1 locationNCT06566482
Recruiting
Not Applicable

Esketamine in Microelectrode Recording-guided Subthalamic Deep-Brain Stimulation for Parkinson's Disease

EsketamineDeep Brain StimulationPD - Parkinson's Disease
Beijing Tiantan Hospital102 enrolled1 locationNCT06543563
Recruiting
Not Applicable

Effect of Esketamine on Conscious State in Patients With pDoC

EsketamineConsciousness Disorders
Beijing Tiantan Hospital116 enrolled1 locationNCT06389344
Recruiting
Not Applicable

The Effect of Dexmedetomidine and Esketamine Combined Infusion Quality of Sleep Undergoing Modified Radical Mastectomy

Dexmedetomidine Plus Esketamine Affect Postoperative Sleep Quality
Anqing Municipal Hospital105 enrolled1 locationNCT06414941