RecruitingPhase 1NCT07607587

Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events

Tolerability of Cagrilintide in People With Obesity That Discontinued GLP-1-RA Therapies Due to Gastrointestinal Adverse Events: a Double-blinded Randomised Feasibility Study


Sponsor

Novo Nordisk A/S

Enrollment

114 participants

Start Date

May 29, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this clinical study is to look at the safety of the medicine Cagrilintide when compared to placebo in people who do not tolerate marketed glucagon-like peptide-1 (GLP-1) therapies and who live with overweight or obesity. Participants will get either Cagrilintide (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participant will get is decided by chance. The study will last for about 8 months.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Cagrilintide and a drug called Placebo (matched to Cagrilintide) for people with obesity and overweight. The study is currently recruiting participants at 11 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCagrilintide

Cagrilintide will be administered subcutaneously.

DRUGPlacebo (matched to Cagrilintide)

Placebo matched to Cagrilintide will be administered subcutaneously.


Locations(11)

Diablo Clinical Research, Inc.

Walnut Creek, California, United States

Northeast Research Institute

Fleming Island, Florida, United States

Jacksonville Ctr For Clin Res

Jacksonville, Florida, United States

Center for Diab,Obes & Metab

Pembroke Pines, Florida, United States

Encore Medical Research of Weston

Weston, Florida, United States

Monroe Biomedical Research, LLC

Monroe, North Carolina, United States

Accellacare

Wilmington, North Carolina, United States

Coastal Carolina Research Ctr

North Charleston, South Carolina, United States

Holston Medical Group_Bristol

Bristol, Tennessee, United States

Amarillo Medical Specialists

Amarillo, Texas, United States

Elligo Clin Res Centre

Austin, Texas, United States

View Full Details on ClinicalTrials.gov

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NCT07607587


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