Phase 1 ACC Clinical Trials
35 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 35 trials
Recruiting
Phase 1
Study of Preoperative Radiation Therapy in Participants With Resectable Recurrent Abdominal Adrenocortical Carcinoma
Adrenocortical Carcinoma (ACC)Carcinoma, AdrenocorticalCarcinoma, Adrenal Cortical+2 more
National Cancer Institute (NCI)32 enrolled1 locationNCT06487481
Recruiting
Phase 1Phase 2
Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors
Solid TumorsAcute Lymphoblastic LeukemiaAcute Myeloid Leukemia+6 more
Incyte Biosciences International Sàrl70 enrolled23 locationsNCT03934372
Recruiting
Phase 1
Effect of Cannabis on E-Cigarette Use Behavior
Cannabis UseTobacco UseElectronic Cigarette Use
Johns Hopkins University100 enrolled1 locationNCT06609109
Recruiting
Phase 1
Clinical Trial of IL - 22BP Safety, Tolerability, and Antitumor Activity in Refractory Solid Tumors.
Refractory Malignant Solid TumorsmRNA VaccineInterleukin
West China Hospital6 enrolled2 locationsNCT07040943
Recruiting
Phase 1
ISP-001: Sleeping Beauty Transposon-Engineered B Cells for MPS I
Mucopolysaccharidosis IH/SMucopolysaccharidosis IS
Immusoft of CA, Inc.11 enrolled2 locationsNCT05682144
Recruiting
Phase 1
A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant
Hematopoietic and Lymphatic System NeoplasmAcute Lymphoblastic LeukemiaAcute Myeloid Leukemia+9 more
City of Hope Medical Center46 enrolled3 locationsNCT07020533
Recruiting
Phase 1Phase 2
Study to Evaluate the Safety and Immunogenicity of a Lyophilized Herpes Zoster Virus mRNA Vaccine
Herpes ZostermRNA Vaccine
Sinovac Biotech Co., Ltd519 enrolled1 locationNCT07400003
Recruiting
Phase 1
Effect of Cannabis on Cigarette Use Behavior
Cannabis UseTobacco UseCigarette Smoking
Johns Hopkins University100 enrolled1 locationNCT06609083
Recruiting
Phase 1
Oral Cannabidiol for Tobacco Cessation
Tobacco Use DisorderTobacco DependenceTobacco Use Cessation+2 more
Johns Hopkins University50 enrolled1 locationNCT05445804
Recruiting
Phase 1
A Clinical Trial Evaluating IL-22BP/LNP Compound in Refractory Malignant Solid Tumors for Safety, Tolerability and Activity
Refractory Malignant Solid TumorsmRNA VaccineInterleukin
Xingchen Peng6 enrolled1 locationNCT07100210
Recruiting
Phase 1Phase 2
Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)
Acute Myeloid LeukemiaMixed Phenotype Acute LeukemiaAcute Lymphoid Leukemia+4 more
University of Florida40 enrolled4 locationsNCT05322850
Recruiting
Phase 1Phase 2
Personalized Neoantigen Peptide Vaccines for Solid Tumors
Solid TumorsAdvanced CancerRecurrent Cancer+2 more
Seqker Biosciences, Inc.10 enrolled2 locationsNCT07002203
Recruiting
Phase 1Phase 2
Accelerated rTMS vs. Sham for Stroke Apathy
StrokeMotivationApathy+4 more
Medical University of South Carolina40 enrolled1 locationNCT07113067
Recruiting
Phase 1Phase 2
Evaluation of Clinical, Perceived and Instrumental Efficacy of a Scar Gel in Preventing Hypertrophic Scars
Safety and EfficacyTopical AdministrationAcceptability Study+1 more
Herbarium Laboratorio Botanico Ltda80 enrolled2 locationsNCT06751433
Recruiting
Phase 1
UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells
Batten DiseaseAdrenoleukodystrophyPelizaeus-Merzbacher Disease+9 more
Joanne Kurtzberg, MD40 enrolled1 locationNCT02254863
Recruiting
Phase 1Phase 2
An Open-label Phase I/II Study of JR-446 in Mucopolysaccharidosis Type IIIB
Mucopolysaccharidosis III-B
JCR Pharmaceuticals Co., Ltd.10 enrolled3 locationsNCT06488924
Recruiting
Phase 1
Effects of Cannabidiol on Stress and Nicotine Withdrawal
StressNicotine DependenceTobacco Smoking+1 more
Johns Hopkins University90 enrolled1 locationNCT07001930
Recruiting
Phase 1Phase 2
Overcoming Nicotine Dependence to Enable Quitting
Smoking CessationSmoking BehaviorsNicotine Dependence+2 more
Rush University Medical Center780 enrolled1 locationNCT05513872
Recruiting
Phase 1
First-in-human Safety and Immunogenicity Study of SCB-1022 and SCB-1033 in Healthy Older Adults
Respiratory Syncytial Virus VaccinationHuman Metapneumovirus VaccinationParainfluenza Vaccination
Clover Biopharmaceuticals AUS Pty192 enrolled1 locationNCT06984094
Recruiting
Phase 1
Thymalfasin (Thymosin Alpha 1; Ta1) as an Enhancer of Vaccine Response Among Older Adults Receiving Booster Doses of COVID-19 Vaccine
Vaccine Response
The Methodist Hospital Research Institute75 enrolled1 locationNCT06821100